Preparation And Performance Of Interventional Catheters With Enhanced Visualization Of Ultrasound Imaging

Ultrasound imaging examinations have been used to track the position of interventional devices such as catheters in the human body in real time.Poor visualization is a major drawback of this technique for guiding catheter intervention.To enhance the ultrasonic visibility of the catheter,a filler having a higher acoustic impedance value(Z value)is introduced into the polymer matrix material to obtain an ultrasound-visible organic-inorganic composite conduit material.In this paper,polyolefin or nylon elastomer was used as the polymer matrix.The ultrasonic reflection coefficient(RI)between the organic-inorganic composite and the bio-substrate was studied by simulation and experiment.influences.Ultrasound image effects of the composite splines in the tissue gel phantom under the experimental conditions of the sink were evaluated using the IMAGE J software.It was found that the loading of the filler and the acoustic impedance of the filler itself play a key role in the acoustic properties and ultrasonic visibility of the composite.For the same filler,the ultrasonic development effect of the composite increases as the filler loading increases;For the same filling amount,when the acoustic impedance value of the filler is lower than 4 times the acoustic impedance value of the bio-matrix,the higher the acoustic impedance value of the filler,the better the ultrasonic development effect of the composite material.However,when the acoustic impedance value of the filler is higher than 4 times the acoustic impedance value of the bio-matrix,the ultrasonic enhancement effect of the filler is continuously increased without significant change.Combined with the processing technology of common conduit materials,the rheological properties of the composite conduit material melt were studied.Based on this,the suitable extrusion processing conditions of the interventional catheter were determined.Through the extrusion process,a small suitable vascular intervention was successfully prepared.An interventional catheter with enhanced caliber visualization.The tensile fracture morphology of the catheter material was analyzed by scanning electron microscopy.The interfacial agent PEG was used to enhance the interfacial interaction between the polyolefin substrate and the inorganic powder particles.The performance comparison before and after the sterilization of the material and the analysis results of the extract indicate the basic requirements of the composite medical application of the composite material;the animal experiment results confirmed that the obtained composite catheter has excellent in vivo ultrasound imaging performance.