Improvement Of Synthetic Technology And Supramolecular Self-assembly Of Cyclopentyl Cucurbituril

Cyclopentyl cucurbituril is a new type of modified cucurbituril.Nevertheless,selenium-containing compounds require doing used in the synthesis process,which has large contamination and low yield.In this paper,the synthesis process of cyclopentyl cucurbituril is improved;and on this basis,the supramolecular self-assembly of cyclopentyl cucurbituril and transition metal ions,inorganic anion complexes and small organic molecules is constructed.1.Two methods were designed to synthesize 1,2-cyclopentanedione.One was prepared from diethyl glutarate and diethyl oxalate by Claisen ester condensation reaction,hydrolysis,and decarboxylation.One is synthesized by using1,3-cyclohexanedione as a raw material and directly catalyzing cracking in aqueous phase at room temperature using Oxone and Al Cl₃.Additionally,phosphorus pentoxide was used to directly catalyze the synthesis of cyclopentyl-substituted glycosides from 1,2-cyclopentanedione and urea in the aqueous phase at room temperature.2.Constructed fully substituted cyclopentano cucurbit[5]uril（CyP₅Q[5]）and fully substituted cyclopentano cucurbit[6]uril（（CyP₆Q[6]））and transition metal compounds（Fe（HClO₄）₃,Co（HClO₄）₂,Ni（HClO₄）₂,Cu（HClO₄）₂,Zn（HClO₄）₂,Co Cl₂）supramolecular self-assembly.Single-crystal X-ray diffraction analyses reveal that the CyP₅Q[5]and Fe（HClO₄）₃,Co（HClO₄）₂,Cu（HClO₄）₂,Zn（HClO₄）₂,and the CyP₆Q[6]and Cu（HClO₄）₂and Zn（HClO₄）₂form a one-dimensional chain supramolecular self-assembly;a CyP₅Q[5]with Ni（HClO₄）₂and a CyP₆Q[6]with Cu（HClO₄）₂And Zn（HClO₄）₂form a molecular bowl-like supramolecular self-assembly.3.The supramolecular self-assembly of CyP₅Q[5]interacting with FeCl₂and FeCl₃on the outer surface,and the supramolecular self-assembly of CyP₆Q[6]interacting with HClO₄and phosphomolybdic acid on the outer surface were constructed.Single-crystal X-ray diffraction analyses reveal that there are holes of different sizes in these complexes.4.The interaction of CyP₆Q[6]and amino acids in the solid and liquid phases was investigated.The results show that the CyP₆Q[6]and amino acids have similar behaviors in solid and liquid phases.