| Tumor imaging diagnosis/treatment integration technology is the frontier and hot spot of cancer research today.MRI diagnosis has the advantages of high resolution,non-invasive and other characteristics.Photothermal therapy of tumor has the advantages of high selectivity,good treatment effect,and small side effects.In this paper,based on the characteristics of lymphatic system tumors,Gd2?CO3?3 nanoparticles were used as templates to prepare Gd/C hollow nanospheres with integrated functions of nuclear magnetic imaging and photothermal therapy by hydrothermal carbonization.The effects of preparation conditions on the Gd2?CO3?3 template and Gd/C hollow nanospheres were studied;the performance of Gd/C hollow nanospheres in light-to-heat conversion,nuclear magnetic imaging,and drug loading were studied.1.GdCl3·6H2O was reacted with urea to prepare Gd2?CO3?3 nanoparticles;the effects of surfactant addition,ethylene glycol addition and reaction time on product shape and size were studied.The results show that within the range of the experimental conditions,the size of nanoparticles decreased with the increase in the amount of surfactant and ethylene glycol,and the extension of reaction time.When the addition amount of surfactant is 0.02 M,the addition amount of ethylene glycol is 10 mL,the reaction temperature is 80°C,and the reaction time is 10 h,spherical particles with a size of 50?60 nm and good dispersion can be obtained.2.Gd/C hollow nanospheres were obtained by using Gd2?CO3?3 nanoparticles as templates and adding glucose for hydrothermal carbonization.The effects of glucose addition,hydrothermal carbonization temperature and hydrothermal time on the product were studied.The results show that the hollowness of the particles will gradually increase with the extension of the reaction time and the increase of the reaction temperature.When the molar ratio of Gd/C is 1:2,Gd/C hollow nanospheres with size of 60?70 nm and shell thickness of 10 nm can be obtained by hydrothermal treatment for 4 h at 200?.3.The photothermal conversion,nuclear magnetic imaging and drug loading properties of the Gd/C hollow nanospheres were studied.The results show that the suspension with a solid content of 1.0 wt%has a photothermal conversion efficiency of24.5%.The lateral relaxation efficiency of the hollow nanospheres is 39.3 L·mmol-1·s-1and the longitudinal relaxation efficiency is 21.9 L·mmol-1·s-1,which is better than the current medical magneville.When the concentration of doxorubicin is 0.2 mg/mL,the drug loading of the hollow nanospheres is 2.63%,and the drug release rate in vitro is 73.7%. |
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