Study On Synthesis,Structure And Properties Of The Nucleotide Polymers

Nucleotide coordination polymer(NCP)have the good biocompatibility and is advantaged containing variety of fluorescence molecular and proteins to act as the subject to transfer the medicine and act as the fluorescent label.Based on this the NCP attracts much attentions.The nucleotide including three parts: purine base(adenine,guanine)or pyrimidine base(cytosine,uracil)and sugar ring,phosphate groups,so the nucleotide has multiple coordination sites(N,O)and show the diversity of the structure.Due to the diversity of nucleotides and the sensitivity to acid,the single crystal structure of nucleotides is difficult to be obtained.In this paper,the coordination polymers of nucleotides and nitrogen-containing ligands were constructed by volatilization.The structure and properties of nucleotides were characterized by IR,powder diffraction,single crystal diffraction,UV,fluorescence and CD.The main results are as follows:(1)Synthesis of monophosphate coordination polymers and 1D belt coordination polymer UMP-Cu-bpda(UMP = Uridine 5'-monophosphate,bpda = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene)were synthesized and their structures and chirality were investigated.Comparison with the 2D UMP-Cu-bpe/bipy(bpe = 1,2-di(pyridin-4-yl)ethylene,bipy =4,4?-bipydine),UMP-Cu-bpda appear 1D structure,this because the length and conjuated of the bpda,bpda provides abundant space for UMP to form base-pair hydrogen bond,which limits bridging role of UMP.The auxiliary ligand in UMP-Cu-bpe/bipy generate extened chirality by the inducing role of UMP,bpda has excellent planarity by ?-? interaction and hydrogen bond produce supramolecular helix chirality.(2)Synthesis of diphosphonic acid coordination polymers and the first diphosphate nucleotide coordination polymer UDP-Zn-4,4'-bipy(UDP = Uridine 5'-diphosphate,4,4'-bipy = 4,4'-bipydine)were synthesized and their structures and chirality were studied.Different form coordiantion modle of monophosphate,diphosphate not only play bridging role but also play chelate role based on its flexibility.It can provide variety of structures.(3)We studied different methods to obtain crystal of rare ions and nucleotides,coordiation complexes by nucleotide and rare have been synthesized,based on this ternaryassembly was obtained.X-ray diffraction(XRD)and scanning electron microscopy(SEM)were used to study the crystallinity and morphology of the coordination polymers.UV,fluorescence and CD spectra were used to study the chirality and fluorescence properties of the complexes.We found auxiliary ligands can enhance fluorescence of the nucleotide coordiantion but it can compete with the nucleotide in the coordiantion process,we choose the properligand obtain ternary assembly with good fluorescence.In this paper,the structure of the coordination polymers was controlled by choosing the appropriate nitrogen-containing ligands,and different chiral signals were obtained by CD.The structure and chirality of the ligands were controlled sucessfully,and the nucleotide and protein coordination modes were simulated,and the use of single crystal structure analysis of the supramolecular assembly of nucleotides,is conducive to further understanding the nucleotide and transition metal coordination mode,chirality transmission and supramolecular assembly.The fluorescence properties of rare earth complexes are favorable for labeling,nuclear magnetic resonance imaging in vivo and the inclusion of biomolecules in drugs.