Purchase Introduction,Experimental Operation And Disease Cases Of Crab Eating Macaque

Background and Purpose:With the rapid development of China's medical industry,the government pays more and more attention to the preclinical drug toxicology research and drug safety evaluation.The requirements of experimental animals are getting higher and hi'gher.Experimental animals attend preclinical drug toxicology research including rodents,rabbits,beagle,Bama miniature pigs and non-human primates.Single experiment showed a trend of comprehensive utilization of experimental animals,the use of experimental animals to show the trend of large sizes and advanced species.In recent years,domestic research using crab eating macaques and other non-human primates have a certain scale and mature supply environment and research background data.Different from other experimental animals,crab eating macaques has more intelligence and personality,feeding and management non-human primate animal is more difficult than others.It has a high risk of experimental operation,and may have significant harm human and animal disease.The experiment process is strictly supervised and restricted by the government,because the crab eating macaques is the second level of the national protected animals in china.This paper introduce and discuss the feeding management and disease control of the crab eating macaque in the preclinical drug toxicology research.Materials and Methods:Based on the author working place:Jiangsu Tripod Preclinical Research Laboratories Co.,LTD,the whole process of a research using crab eating macaques as the background,combined with some crab eating macaques related disease control examples,Divided into 3 chapters:Purchas introduction,eperimental operation and disease cases introduce and discuss how reasonable and legitimate use the crab eating macaque as experimental animals.Purchas introduction section include:?The preparation work before monkey buying and leading into the experimental institutions,?Reception and quarantine,experimental operation section include:?Grasping in conscious state,?Adaptation and training,?Fixed and experimental operation,?Execution and anatomy,?Experiment closeout.Among them the preparation work include 4 parts:Approval of animal use within the organization,animal supplier survey,Sign Animal purchase contracts,administrative examination and approval procedures for the application of the second level protection of animals in china.Reception and quarantine include 3 parts:Screening of blood biochemical and physiological data,Transport and receiving,Quarantine period works.The next 3 parts:Grasping in conscious state,Adaptation and training,Fixed and experimental operation are introduction and descriptibn operation and matters needing attention in research use eating crab monkeys.Execution and anatomy has 2 parts:Experiment plan execution and Euthanasia.Experiment closeout is constitute by 4 parts:Harmless disposal of dead bodies,drug cleaning period and reuse,donation and return visit exanple,Feedback to the administrative department of the monkey's disposal.Disease cases section to introduce the idea and method of preventing and controlling the disease in experiment.It includes 3parts:?ental illness and animal welfare,?Sequelae of drug toxicity test,?Accident.Conclusions:In this paper,use examples,photographs and charts introduce and discuss the complete process in preclinical drug toxicology research which using crab eating macaques.In order to provide a reasonable and legitimate way to use crab eating macaque as,experimental animals in china.