Pathology Simulation Research Of Short QT Syndrome Based On The Model Of Left Ventricular Myocytes

The heart is one of the most important organs.At present,the heart disease has become the common pathema affecting human life and health greatly.If animal experiment was adapted to research the pharmacology,it had more difficult problems to deal with.If computer model was used to simulate the electrophysiological activities,it would provide better security to develop drugs economically.Genetic forms of the Short QT Syndrome(SQTS)arise due to cardiac ion channel mutations increases the sudden cariac death,it has vital significance to the pathological study of short QT syndrome.By consulting relative literature,this thesis used the ten Tusscher,Noble,Noble and Panfilov(TNNP)human ventricular cell model to study.First,simulate action potential for single myocardial cell and build the process of action potential propagation through 1D myocardial cell.Then simulates the action potential propagation in 2D tissue of ventricular myocytes based on 1D myocardial cell,and calculated the ventricular components of ECG,namely pseudo-ECG.Ventricular myocytes cells have tow proportions,include 4:3:4 and 25%:35%:40%,by compared simulation results with clinical experiments,the proportion of 4:3:4 is better than the other one.The heart is both an electrical and mechanical organ,so this thesis simulate the human ventricular myocyte electromechanical cell model.This thesis researched the Ikr-channel-linked short QT variant 1,IKs-channel-linked short QT variant 2 and Ikl-channel-linked short QT variant 3.Respectively,the Markov chain IKr model and the Hodgkin-Huxley IKs and IKl model formulations were incorporated into 2D tissue model and single ventricular myocyte electromechanical cell model to gain the action potential,the action potential propagation in 2D tissue model and pseudo-ECG et al.Compared simulation results with clinical experiments,to research the mechanism of arrhythmia due to the short QT syndrome.With Vistual Studio 2010,this thesis uses the C++ programming to designs and realizes the simulation system of action potential propagation in the 2D tissue and singl left ventricular myocyte electromechanical cell model.Got SQT1 SQT2 and SQT3 simulation data,which were visualized by Matlab.By analyzing pathological properties,it is shown that the simulation results are consistent with clinical data.