The Effects Of Childhood Trauma On Sympyoms And Efficacy Of Schizophrenia

Objective: This study attempts to explore the incidence of child hood traumatic experiences in schizophrenia and normal population,and the influence of childhood trauma experience on schizophrenia symptoms and curative effect.In order to find the risk elements correlated with childhood experience,effective intervention in the prodrome can reduce the incidence of schizophrenia.Methods: The patients with schizophrenia group and the control group were set up in this study.The subjects in the treatments were schizophrenia patients who corresponding to diagnosis standars,and hospitalized in Fourth People's Hospital of Wuhu from November 2016 to September 2017 to meet the standard of schizophrenia.142 subjects were join in the group,and 100 cases were completed in the end.The patients with schizophrenia group subjects finish the self-designed general questionnaire,Childhood Trauma Q uestionnaire-Short Form(CTQ-SF)at baseline,and the evaluation of The Positive and Negative Syndrome Scale(PANSS)by the researchers.Used the PANSS to assess the subjects in the second,fourth,sixth week of the hospitalization,and the subjects with higher coordination were selected to fill in C TQ-SF again in the sixth week of hospitalization.The subjects in the control group were normal subjects corresponding to the gender,age and educational background of the experimental group.The general questionnaire and C TQ-SF were filled out by the subjects,sum to 130 questionnaires were hand out,and 120 copieswere finally completed.Results:(1)The proportion of people with religious beliefs in the treatment group was noteworthy exceed the normal matched group.The proportion of schizophrenia patients at 0-6 years old only accompanied by fathers or mothers was less than that of the control group,while the proportion of parents are accompanied and parents are not accompanied.has no distinction with the normal matched group.(2)The Alpha reliability coefficient of the childhood trauma questionnaire of the schizophrenic group was 0.821,the half reliability was 0.760,and the retest reliability was 0.944.The Alpha reliability coefficient of the normal control group was 0.763,and the split-half reliability was 0.674.There was a sub-high relate between the dimensions of childhood trauma questionnaire in schizophrenia group and normal control group,and the relate between each divisor and aggregate score was greater than that among all dimensions.Confirmatory factor analysis showed that the data of two groups of schizophrenia and normal control group were RMSEA < 0.08,1 < CMIN/DF < 2,GFI,AGFI,CFI,TLI and PCFI were all greater than 0.7.(3)Incidence of childhood emotional abuse,physical abuse,sexual abuse,emotional neglect,physical neglect were reported by: 18%,22%,21%,42% a nd 64% of the schizophrenia patients respectively.Incidence of childhood emotional abuse,physical abuse,sexual abuse,emotional neglect,physical neglect were reported by: 13%,8%,15%,23% and 36% of the normal control.In schizophrenia patients and normal control,there was remarkable distinction in the occurrence rate of physical abuse,sexual abuse,emotional neglect,and physical neglect(P < 0.05),and there was a significant difference in the total score and the scores of all the factors in the CTQ-SF(P<0.05).(4)There was no remarkable distinction in the rate of PANSS score reduction among patients with childhood trauma experience and non-childhood trauma(P >0.05).There was no remarkable distinction in the rate of PANSS score reduction in patients with or without emotional abuse,physical maltreat,sexual truama,emotional overlook,and physical neglect(P>0.05).(5)The first hospitalized patients scored significantly higher in the P2(scattering of association)and G14(lack of impulse control)than the non-first hospitalized patients.There were remarkable distinctions in the scores of positive symptoms,P7(hostility),N5(difficulty in abstract thinking)and G9(unusual though content)between patients with emotional abuse and patients without emotional abuse(P<0.05).There were remarkable distinctions in the scores of P6(suspiciousnes/ persecution)and G9(unusual though content)between patients with physical abuse and patients without physical abuse(P < 0.05).There was remarkable distinctions in the scores of N5(difficulty in abstract thinking)between patients with sexual abuse and patients without sexual abuse(P<0.05).There were remarkable distinctions in the scores of G2(anxiety),G6(depression),G10(disorientation),G13(disturbance of volition),G15(preoccupation)between patients with physical neglect and patients without physical neglect(P<0.05).There was no remarkable distinctions in the scores of PANSS items for patients with emotional neglect and no emotional neglect(P>0.05).(6)There was statistically significant difference in the reduction rate of negative symptoms between the patients whose father go out to work between his or her 0-16 years old(P<0.05).Conclusions:(1)The childhood trauma questionnaire has good reliability and validity in schizophrenia patients.(2)The incidence of childhood trauma in schizophrenic patients is higher than that in normal population.The degree of emotional abuse,physical abuse,sexual abuse,emotional overlook and physical neglect is higher than that of normal population.(3)Traumatic experience in childhood has no remarkable influence on the efficacy of schizophrenia.Father not go out to work between the patients 0-16 years of age has a positive effect on negative symptoms.(4)Patients who suffered emotional abuse in childhood showed more obvious positive symptoms.O n the other four factors have no significant impact on the symptoms of schizophrenia.