The Potential Roles Of Serum NSE(neuron Specific Enolase),BNP(b-type Natriuretic Peptide)and D-dimer Levels In Prediction Of Exacerbation Of COPD

Objective To explore the clinical significance of NSE,BNP and D-dimer levels in predicting acute exacerbation of COPD(AECOPD).Methods eighty-seven patients with AECOPD,eighty-seven patients with COPD and 50 healthy volunteers who met with the criteria were enrolled in this study,the serum levels of NSE,BNP and D-dimer were determined by immunoradiometric assay,fluorescence immunoassay,and Turbidimetric inhibition immunoassay separately.The levels of NSE,BNP and D-dimer in patients with acute exacerbation of COPD(AECOPD)and the stable COPD patients,patients with acute exacerbation of COPD(AECOPD)and group of 50 healthy volunteers.Results the levels of NSE,BNP and D-dimer levels in patients with acute exacerbation of COPD(AECOPD)were significantly higher than those in group of 50 healthy volunteers(P<0.05),and those in the stable COPD patients(P<0.05).Conclusions Dynamic monitoring of plasma NSE,BNP and D-dimer levels may predict the acute exacerbation of COPD.