Ultra-low Frequency Pulse Current Acupoint Irradiation Therapy Efficacy And Safety Of Nonalcoholic Fatty Liver Disease

Objective:1.To observe different type of traditional Chinese medicine of the clinical characteristics of patients with nonalcoholic fatty liver disease;Chapter 2.The ultra-low frequency pulse current door acupoint irradiation treatment on clinical outcomes in patients with nonalcoholic fatty liver disease(liver function,blood fat,liver ultrasound backscattering integral scale,such as fatty liver index change);3.in patients with nonalcoholic fatty liver disease in ultra-low frequency pulse current chapter door acupoint irradiation treatment adherence;Chapter;4.The ultra-low frequency pulse current door acupoint irradiation therapy in patients with nonalcoholic fatty liver disease of adverse reactions.Chapter discusses ultra-low frequency pulse current door acupoint irradiation treatment was applied to the clinical significance in patients with nonalcoholic fatty liver disease,for nonalcoholic fatty liver disease prevention,diagnosis,treatment,provides the basis.Methods:83 patients with nonalcoholic fatty liver disease.Were randomly divided into treatment group and the control group,two groups of patients was detected in the liver function,blood fat,liver ultrasound backscattering integral parameter,fatty liver index,analgesia nociceptive index.Two groups of patients were to be two ammonium glycyrrhetate injection by intravenous infusion of 150 mg,once per day.Injection with reducing glutathione 2.4 g,once a day.On this basis,the treatment group patients with HD-91 type II chapter door acupoint irradiation liver disease therapeutic apparatus ultra-low frequency pulse current treatment for 30 min,morning 9 began to once a day,once a day.Patients received three courses of treatment,each period of treatment is 15 days,after a course of 7 days of rest and then continue to the next course of treatment.Treatment process was carried out on the patient's psychological and diet instruction,reduce the offset observation data.Again after the three courses of treatment of two groups of patients was detected in liver function,blood fat,liver ultrasonic backscatter integration,fatty liver index,analgesia nociceptive index,the test results,compliance of patients in the process of treatment and analysis of adverse events.Two groups were in June 2011 to June 2014 in nanjing second homes and liuhe district people's hospital of hospitalized patients.On the basis of traditional Chinese medicine new medicine clinical research guiding principles(try out)"African alcoholic fatty liver,the curative effect of standard drafting.For all who meet the following four recent cured,satisfy 3 person to pay off,to effectively meet two,did not meet the effective standard as invalid:(1)B ultrasonic examination of ultrasonic backscatter integration,namely the average image intensity(averageimageintensity,All),the standard deviation of image intensity(standarddeviation ofimage intensity,SDI)and other image peak intensity(peaktopeakintensity,PPI)these three ultrasound integral,at least 2 B to exceed integral indicators for each lower than before treatment,1 or more than 1 minute to effectively;(2)Alanine transferase(Alanine transaminase,ALT),serum Total cholesterol(Total cholestero,TC),triglyceride(Triacylglycerol,TG)and the FLI agreed,returned to normal BMI range or falls 40%or more;(3)The check-up liver obviously retraction;(4)The clinical symptoms improved significantly,syndrome integral decline 70%or higher.TCM syndrome integral standard:according to the clinical symptoms of light,medium and heavy degree 1,2,3 points,respectively.Calculating formula for[(before points-points after treatment)before present treatment of integral]x 100%.Results:1,The basic situation:in patients with the control group a total of 41 cases,20 male,female 21 cases,age are mainly distributed in 27 to 68,the median age of 49.4 years old,average duration of 3.7+/-1.21 years,body mass index of 23.4 +/-2.3 kg/m2;According to the type of traditional Chinese medicine,including 12 cases change the type,phlegm turbidity indicates the resistance type 9 cases,hot and humid intrinsic type 8 cases,6 patients with phlegm and blood stasis mutual junction,6 cases of liver and kidney deficiency type;Fat index the FLI agreed to average 66.74+8.27.Treatment group(42 cases,21 cases of men,women,21 cases are mainly distributed in age between 26 and 69-year-old,flat median age 49.7,average duration 3.6 +/-1.19 years,body mass index of 23.7 +/-2.5 kg/m2;According to the type of traditional Chinese medicine,including 12 cases change the type,phlegm turbidity indicates the resistance type 9 cases,hot and humid intrinsic type 8 cases,6 patients with phlegm and blood stasis mutual junction,liver and kidney deficiency type 7 cases;The FLI agreed to average 67.26 + 8.08.Two groups of patients with all natural material,have no significant statistical difference.Two groups of patients with liver,Fatty liver index(Fatty liver index,the FLI agreed),Body mass index,Body mass index,BMI)and blood lipids were no significant statistical difference.2 According to the type of traditional Chinese medicine,patients are divided into 5 groups,respectively to change type,phlegm turbidity indicates the resistance type,hot and humid embodiment,mutual junction of phlegm and blood stasis,liver and kidney deficiency type,the various indicators analysis,including intrinsic group of liver function of lactate dehydrogenase,lactate dehydrogenase,LDH)284.28 + 25.33 U/L,Alanine transaminase(Alanine transaminase,ALT)256.6 + 20.13 U/L,FLI71.7+/-8.27,Total bile acid(Total bile acid,associates)34.68 +/? 2.43 umol/L,Analgesia-damage index(Analgesia nociceptive index,ANT)1.56 +/-0.25 numerical than other groups apparently unusual,was statistically significant,P<0.05).3,Treatment effect:the treatment group cure 3 cases(7.3%),12 cases were markedly improved(29.3%),24 cases(58.5%),effective invalid in 2 cases(4.9%),the total effective rate was 95.1%.Control group cure 0 cases(0%),5 cases were markedly improved(11.9%),18 cases(42.9%),invalid 19 cases(45.2%),the total effective rate was 54.8%.Two group total effective rate comparison,the chi-square test,there are significant differences(X2 =8.65,P = 8.65).4,The treatment group before and after treatment,liver function,blood lipids,ultrasonic backscattering integral,fatty liver,analgesia-harmful index,the contrast analysis,the indicators are significantly improved after treatment(P<0.05),the control group were also all the indexes were obviously improved after treatment(P<0.05)in the treatment group compared with control group after treatment related data difference obvious(P<0.05),and the treatment group is better than that of control group,with statistical significance.Conclusions:1.Nonalcoholic fatty liver disease patients after press of traditional Chinese medicine,including intrinsic group of LDH in the liver,ALT,the FLI agreed,associates,ANI numerical than other groups obviously abnormal;2,Can be observed in this study,in the before and after treatment,the FLI agreed with ultrasonic backscatter integration are improved,according to index of nonalcoholic fatty liver disease patients with fatty liver and liver backscatter integration has good consistency,the prevention,diagnosis,clinical treatment of nonalcoholic fatty liver disease to provide the new beneficial exploration.3.Treatment group and control group after treatment liver function,blood fat,liver IBS and the FLI agreed were improved significantly,but the two groups total effective treatment have significant difference,the treatment group total effective rate is higher;4.Liver area pain,loss of appetite,abdominal distension,deterioration of liver function and other adverse events,the treatment group and control group no significant difference.