Clinical Analysis Of Inpatients With Inflammatory Bowel Disease In The Recent 10 Years

Purpose: To investigate the clinical changes of IBD in recent 10 years by reviewing the clinical data of inpatients with inflammatory bowel disease(IBD)in Anhui Provincial Hospital.method: Collecting hospitalized patients newly diagnosed as IBD from January 2008 to November 2017 in Anhui Provincial Hospital,counting the number of IBD cases in each year,recording the age,sex,extraintestinal symptoms,complications,imaging,internal The results of the mirror,the number and number of endoscopic biopsies,histopathological findings,therapeutic drugs,and surgical conditions were divided into two groups according to time,January 2008-December 2012(Group A)and January2013-2017 November(B group),respectively,compared UC and CD in the two groups admitted to the clinical characteristics and diagnosis and treatment of the difference.result:1): A total of 515 IBD cases were collected from 2008 to 2017,including 358 UC patients(69.51%)and 157 CD patients(30.49%).The number of UC cases increased by 3.72 times and the CD increased by 3 times from 2013 to 2017 Times.2)The ratio of male to female in group A was 75/61(1.23: 1)in group A,and 130/92(1.41: 1)in group B,with mean age at diagnosis being 44.40 ± 14.32 years and 41.16± 13.50 years respectively.Chronic relapsing was most common in both UC patients.A group mainly involved the left colon(n = 65,47.79%)and the group B(n = 121,54.50%)(P <0.05).Patients in group A were predominantly mild(n = 54,39.70%)and moderate(n = 62,45.59%)while patients in group B were moderate(n = 125,56.31%)and severe(n = 61,27.48%)Patients was significantly higher(P <0.05).3): The ratio of male to female in group A was 24/17(1.41: 1)in CD patients,74/42(1.76: 1)in group B,and the average age at diagnosis was 35.98 ± 15.74 and 31.24± 10.93 years respectively.More than half of group B Complications of CD patients(50.86%),which merged perianal lesions than the A group was significantly increased(P <0.05).According to Montreal classification,the proportion of CD patients diagnosed in group B between 17 and 40 years(n = 87,75%)was significantly higher than that of group A(n = 23,56.10%)(P <0.05).The main lesion sites in both CD patients were all ileocolic.The proportion of patients with B in the group B was significantly increased(46.34% in group A,65.52% in group B)(P <0.05).The main disease behaviors of CD patients were non-stenosis non-penetrating(Group A: 65.85%,group B: 55.17%).The proportion of stenosis and penetrating CD in group B was significantly higher than that before(P> 0.05).Patients in group A were predominantly mild,patients in group B were moderately active,and patients in moderate activity were significantly increased in group B(group A: 31.70%,group B: 50.86%)(P <0.05).4): The proportion of colonoscopy and biopsy in group B was significantly higher than that in group B(P <0.05).The average number of endoscopic biopsy sites in group B was significantly higher than that in group A(P> 0.05).In group B,the detection rate of typical pathological changes of IBD patients increased compared with the former,of which,UC mainly manifested in diffuse inflammatory cell infiltration,crypt abscess and recessive structure abnormalities in the three mirrors(P <0.05),CD Reflected in case of non-caseous granuloma,ulceration and fissure-like chronic inflammatory cell infiltration(P <0.05).80.17% of CD patients in group B underwent CT intestine imaging(CTE)examination,which was significantly higher than that of group A(39.02%)(P<0.05).Group B IBD combined with clinical manifestations,colonoscopy and biopsy pathological changes in the proportion of comprehensive diagnosis was significantly increased(P <0.05).5): The proportion of UC patients treated with hormones(group A: 20.59%,group B:46.40%)and immunosuppressive agents(group A: 2.21%,group B: 7.21%)was significantly increased(Group A: 39.02%,group B: 66.38%)and biological agents(group A: 9.76%,group B: 36.21%)were significantly higher than those before(P <0.05).The main treatment of UC patients in group A was SASP / 5ASA combined with topical treatment(n = 64,47.06%).In group B,hormone combined with SASP / 5ASA(group A:18.38%,group B: 37.83%)(P <0.05).or immunosuppressant A group: 2.21%,B group:8.56%)(P>0.05)treatment of UC patients was significantly increased.The main treatment of CD patients in group B was biologic agent combination immunosuppressant(n = 39,33.62%),followed by hormone combination immunosuppressive agents(n = 22,18.97%)and biological agents combined with immunosuppressants %,B group: 33.62%)treatment of CD patients was significantly higher(P <0.05).In addition,the proportion of CD patients who chose enteral nutrition combined with immunosuppressive agents in group B(group A: 7.31%,group B:13.79%)was significantly increased(P>0.05).Conclusion: In recent 10 years,the newly diagnosed IBD hospitalized patients in Anhui Provincial Hospital have shown an overall growth trend,and the number of IBD admissions in recent five years has increased significantly year by year.The number of UC cases increased 3.72 times and that of CD increased 3 times.In the recent 5 years,our hospital IBD hospitalized patients compared with the first 5 years of clinical and biological characteristics of the change,the complexity and severity of the disease is higher,our hospital IBD diagnosis methods and treatment has changed,the diagnosis level Significantly improved before.