Analysis Of Platelet And Coagulation Function In Patients With Inflammatory Bowel Disease

Objective: To study the related factors of hypercoagulability in patients with inflammatory bowel disease and their relationship with CRP,ESR and DD,and to screen out the population with the highest risk of hypercoagulation,so as to prevent the formation of thrombosis in the early stage.Methods: Patients with inflammatory bowel disease(IBD)hospitalized in the department of gastroenterology,Peking union medical college hospital,Wuhan city were selected.According to the consensus opinions on the diagnosis and treatment of IBD in Beijing in 2018,139 cases meeting this diagnostic standard were included in the diagnosis criteria and divided into UC group and CD group according to the diagnostic classification.The patients were divided into groups of 0-20 years old,20-40 years old,40-60 years old and 60-80 years old,and divided into male and female according to gender.The patients with UC was divided into mild group,moderate group and severe group according to the improved Truelove and Witts severity.Choose patients hospitalized in Wuhan union hospital with polyps of digestive diseases as normal control group.Record data about blood routine examination,coagulation function and DD.Regard PLT and coagulation function as the patient's blood coagulation state.Compare PLT and coagulation function from patients with inflammatory bowel disease and with polyps.Analyze the relationship between PLT and CRP,ESR,DD.Use SPSS 20.0 software to analyze data.Results: 1.There were statistical differences in PLT,TT and FIB between patients with inflammatory bowel disease and those with polyps(P < 0.05),but no statistical differences in APTT.2.There was no statistical difference between patients with UC and patients with CD in PLT,TT,FIB and APTT.3.There was no statistical difference in the analysis of PLT,TT and FIB among IBD patients in terms of age.PLT of IBD patients showed statistical difference in gender, while TT and FIB showed no statistical difference in gender;PLT was moderately correlated with ESR,slightly correlated with CRP,but not correlated with DD.4.PLT of CD patients showed statistical difference in gender and age,while TT and FIB showed no statistical difference in gender and age.PLT was moderately correlated with ESR,and was moderately correlated with CRP,but not with DD.5.There were no statistical differences in PLT,TT and FIB among UC patients in terms of gender and age;PLT and FIB was statistically different in the disease severity with the active phase,while TT was not statistically different.PLT had low correlation with ESR and DD,but no correlation with CRP.Conclusion: 1.IBD patients have higher coagulation status than normal people;2.The hypercoagulability of IBD patients has no connection with the type and age of diagnosis.PLT of female patients is higher than that of male patients,and the risk of hypercoagulability of female patients is higher than that of male patients.The hypercoagulability of IBD patients was correlated with ESR,but not with CRP and DD.3.The higher the age of CD patients,the higher the risk of coagulation.The hypercoagulability of CD patients was correlated with ESR,but not with CRP and DD.4.The risk of hypercoagulability in UC patients was independent of gender and age;The more serious the condition was in the active stage,the more significant the hypercoagulability was.The hypercoagulability of UC patients has little correlation with ESR and DD,but no correlation with CRP.