The Clinical Observation Of Retinal Nerve Fiber Layer Thickness And Pattern Visual Evoked Potential In Diabetic Patients

Purpose:To observe the changes of peripapillary retinal nerve fiber layer(RNFL)thickness,retinal thickness and volume of macular and the pattern visual evoked potential(PVEP)in diabetic patients.Methods:The diabetic patients were diagnosed according to the World Health Organization diabetic diagnostic criteria.Sixty-four eyes of thirty-five patients with,no diabetic retinopathy(NDR)were grouped as NDR group.Sixty eyes of thirty-two patients with primary diabetic retinopathy(DR)were grouped as DR group.Sixty-eight eyes of thirty-four healthy volunteers were enrolled to the control group with age,sex,visual acuity and intraocular pressure(IOP)matched.The medical history,the fasting blood glucose,glycated hemoglobin Alc(HbA1c)and blood pressure were recorded.All participants underwent the basic ophthalmic examination:visual acuity,IOP,ocular axial length,anterior and fundus segment examination.The peripapillary RNFL thickness,retinal thickness and volume of macular were detected by optical coherence tomography(OCT).P100 latency and amplitude of PVEP were evaluated by the visual electrophysiology detector.All participants accepted the examinations and signed the informed consent form voluntarily,and the same examination was performed by the same inspector in the same conditions.SPSS22.0 for windows statistical software was used to analyze the results.Results:There was significant difference in superior,nasal,temporal quadrants and global average of RNFL thickness between NDR group and control group(all P<0.05).The The peripapillary RNFL thicknesses of DR group was significantly thinner than the control group in superior,inferior,nasal quadrants and global average(all P<0.01).All quadrants of RNFL thickness in DR group were significantly thinner than the NDR group(all P<0.05).The macular retinal thickness of A3,A4,A5,A6 and A8 area in NDR group was significantly thicker than the control group(all P<0.05).Compared with the control group,the retinal thickness of A3,A4,A5,A6,A7 and A9 area in DR group was significantly thicker(all P<0.05).There was no significant difference in all area of macular retinal thickness between NDR group and DR group(all P>0.05).The macular retinal volume of A3,A4,A5,A6 and A8 area in NDR group was significantly larger than the control group(all P<0.05).Compared with the control group,the retinal volume of A3,A4,A5,A6,A7 and A8 area in DR group was significantly larger(all P<0.05).There was no significant difference in all area of macular retinal volume between NDR group and DR group(all P>0.05).The P100 latency of NDR group was significantly longer than the control group(P<0.01).For the P100 amplitude,the NDR group was lower than the control group,but there was no significant difference between the two groups(P>0.05).Compared with the control group,the P100 latency was prolonged and the amplitude was decreased significantly in the DR group(Platency<0.01,Pamplitude<0.05).T he P100 latency was prolonged and the amplitude was decreased in the DR group compared with the NDR group,and there was significant difference between the two groups(P<0.05).The P100 latency of each group was negatively correlated with the peripapillary RNFL thickness in superior,inferior,nasal,and global quadrants(all P<0.01).The P100 amplitude was positively correlated with all quadrants and global average of RNFL thickness(all P<0.05).Conclusion:Diabetes could decrease the RNFL thickness of the peripapillary,increase the retinal thickness and volume of macular and weaken the visual conduction function.