| Background: Metabolic syndrome(MS)is clustering of various metabolic parameters including abdominal obesity,hypertension,dyslipidemia and hyperglcaemia.It has become a global major public health problem,particularly severe in China.The relationship between metabolic syndrome and hyperuricemia,hyperuricemia and throid function,throid function and metabolic syndrome have become the focus of medical research.Objectives: Analysising the mutual relation of MS including its components,serum uric acid(SUA)and thyroid function indexes in a Nanning community crowd,exploring the correlation about MS,hyperuricemia and thyroid function and discussing their clinical value.Methods: Randomly selected 578 employees(age>30)including retirees in a community crowd of Guangxi Nanning to participate in the cross-sectional epidemiological investigation in October 2016 to November 2016.Detecing their waist circumference(WC),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),fasting blood-glucose(FBG),serum uric acid(SUA),free thyroxine(FT4),free triiodothyronine(FT3),thyroid stimulating hormone(TSH)and etc,searching the interrelation of metabolic syndrome including its components.hyperuricemia and thyroid function.Results: 1 The prevalence of MS in community crowd(age > 30)was18.5%(107/578).2 what about the interrelation between MS and SUA?2.1 The relationship between MS and SUA reflected in SUA(401.02±94.52umol/L)in MS group was higher than SUA(335.98±97.28 umol/L)in non-MS group.2.2 The relationship between abnormal metabolism of MS components and SUA reflected in SUA(393.48±101.74 umol/L),(373.86±93.83 uoml/L),(380.65±97.04 umol/L),(381.46 ± 105.49 umol/L)in abdominal obesity group,high fasting glucose group,hypertension group and dyslipidemia group were higher than SUA(335.08±95.67 umol/L),(342.93±100.42 umol/L),(327.96±96.48umol/L),(326.39±89.93 umol/L)in normal waist circumference group,normal fasting blood glucose group,normal blood pressure group and normal blood lipid group.2.3 The relationship between HUA and MS reflected in WC(83.83±10.19 cm),SBP(132.23 ± 17.58 mmHg),DBP(80.14 ± 9.78 mmHg),TG(2.00 ± 1.35mmol/L)in HUA group were higher than WC(75.98±14.22 cm),SBP(122.94± 17.70 mmHg),DBP(75.14 ± 10.14 mmHg),TG(1.31 ± 0.84 mmol/L)in normal SUA group,HDL-C(1.34±0.39 mmol/L)in HUA group was lower than HDL-C(1.34 ± 0.39 mmol/L)in normal SUA group.With the increasing of combined metabolic components,the prevalence of hyperuricemia was increasing,but there was no statistically significant difference.2.4 The correlation between SUA and MS indexes reflected in SUA was positively correlated with WC,SBP,DBP,TG;negatively correlated withHDL-C and not significant correlated with FBG.3 What about the relationship between MS and thyroid function?3.1 The relationship between MS and thyroid function reflected in FT3(4.72±1.28 ug/dl)in MS group was higher than FT3(4.52±0.81 ug/dl)in non-MS group.(P<0.05)3.2 The relationship between the components of MS dysbolism and thyroid function reflected in TSH(3.12±4.31 mIU/L)in abdominal obesity group was higher than TSH(2.29±1.61 mIU/L)in normal group,FT4(15.71±2.40 ug/dl)in abdominal obesity group was lower than FT4(16.55±2.50 ug/dl)in normal group.FT3(4.73 ± 1.32 ug/dl),(4.72 ± 1.28 ug/dl)in high FBG group and hypertension group were higher than FT3(4.52±0.81 ug/dl),(4.46±0.57 ug/dl)in normal waist circumference group.TSH(2.74±3.22 mIU/L)in dyslipidemia group was higher than TSH(2.31±1.86 mIU/L)in normal blood lipid group,FT4(16.06±2.83 ug/dl)in dyslipidemia group was higher than FT4(16.55±2.25 ug/dl)in normal blood lipid group.With the increasing of combined metabolic components,the prevalence of hyperthyrotropinemia was increasing.3.3 The correlation between thyroid function indexes and MS indexes reflected in FT3 was positively correlated with FT4,WC,SBP,DBP;and negatively related with TSH,HDL-C.TSH was negatively correlated with FT3,FT4,HDL-C;and positively correlated with WC,TG,FBG;and not obviously associated with SBP,DBP.4 what was the relationship between SUA and thyroid function?4.1 HUA and thyroid function: FT3(4.70 ± 1.07 ug/dl)in HUA group was higher than FT3(4.49±0.83 ug/dl)in normal SUA group.4.2 The correlation between SUA and thyroid function indexes reflected in SUA was positively correlated with FT3,FT4,and was not associated with TSH.5.The relationship between age and various indicators: The largest number of HUA patients were appeared in the age of 30-39 years old.The largest number of abdominal obesity patients,high blood pressure patients,high TG patients and low HDL-C patients were appeared in the ages 40 to 49.The largest number of high TSH patients were appeared in the ages 50 to 59.The largest number of high FBG patients and MS patients were appeared in the age of 60-69 years old.The prevalence of High TSH,HUA,abdominal obesity,high TG,FBG,high blood pressure,and even the prevalence of MS in each age group was statistically significant different.Furthermore,the prevalence of abdominal obesity,high FBG,high blood pressure,and even the prevalence of MS had rising trend with the increasing of age,the prevalence of low HDL-C was not found obvious difference with the growth of the age.Besides,Age was positively correlated with TSH,SUA,WC,SBP,DBP,TG,FBG;and was negatively correlated with FT3,FT4.There was no obvious correlation between age and HDL-C.Conclusion:In the study,the relationship between MS and SUA reflected in SUA was increasing in MS group,abnormal metabolism of MS components could cause SUA increased,and the prevalence of HUA increased with the increase of combined components of MS,while HUA could cause abnormal metabolism of MS components or MS;the relationship between MS and thyroid function indexes reflected in FT3 in MS group was higher than FT3 in non-MS group,TSH increased and FT4 decreased in abdominal obesity group and dyslipidemia group,FT3 in hyperglycemia and hypertension group increased.The prevalence of hyperthyrotropinemia had a rising trend with the increasing of combined metabolic components.The relationship between SUA and thyroid function indexes showed as FT3 in HUA group increased.Except for FT4,mostof the remaining indicators closely related to each other.TSH,SUA,WC,SBP,DBP,TG,FBG level were increasing with the increasing of age and FT3,FT4 level were declining with the increasing of age.Furthermore,the prevalence of High TSH,HUA,abdominal obesity,high TG,high FBG,high blood pressure,and even the prevalence of MS in each age group was statistically significant different.The prevalence of abdominal obesity,high FBG,high blood pressure,and even the prevalence of MS had rising trend with the increasing of age,the prevalence of low HDL-C was not found obvious difference during the growth of the age.MS,hyperuricemia and throid function were closely related to each other,Detections of serum uric acid and thyroid function have important significance in health screening and clinical treatment of metabolic syndrome. |
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