Analysis Of Clinical Features Of HBV Infection Complicated With Type 2 Diabetes

Objective:Retrospectively analyzed clinical data and related biochemical indicators such as blood glucose,C peptide,insulin and liver function in patients with HBV infection complicated with type 2 diabetes mellitus,to understand the characteristics of changes in glucose metabo-lism related indicators in these patients,and provides assistance for the individualized diagnosis and treatment of HBV-infected patients with type 2 diabetes.Methods:Selection a total of 159 cases from Department of Endocrinology,First Affiliated Hospital of Guangxi Medical University between 2012-2017 with HBV infection complicated with type 2 diabetes mellitus as the observation group.Randomly selected 110 patients with type 2 diabetes without HBV infection as control group.Collect all the patients gender,age,duration of diabetes,family history of diabetes,body mass index(BMI),fasting plasma glucose,postprandial 2-hour blood glucose,fasting C-peptide,2-hour postprandial C-peptide,fasting insulin,2 hours postprandial insulin,glycosylated hemoglobin,alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin,albumin,globulin,HBV infection course,HBV-DNA quantitative and other indicators,stratified analysis those indicators based on diabetes duration and HBV-DNA quantitative in both groups.Results:1.Observation group 159 patients with HBV infection and type 2diabetes,110 patients with type 2 diabetes without HBV infection in the control group,the general condition of the two groups of patients:age,duration of diabetes,family history of diabetes,and BMI were not significantly different(p>0.05).Fasting C-peptide,C-peptide 2 hours after meal,albumin in the observation group are lower than the control group,alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin and globulin arehigher than the control group,the difference was statistically significant(P<0.05).There is no significant difference in fasting blood glucose,2 hours postprandial blood glucose,glycated hemoglobin,fasting insulin,and 2 hours postprandial insulin between the two groups(P>0.05).2.Independent stratification of newly developed patients with type 2diabetes in Observation and control group,60 cases of newly developed type 2 diabetic patients in the observation group and 50 cases in control group.The fasting C peptide and postprandial 2 hour C peptide in the observation group were lower than those in the control group with newly diagnosed type 2 diabetes mellitus,total bilirubin,alanine aminotrans-ferase,aspartate aminotransferase,albumin and globulin were higher than those of the control group with newly diagnosed type 2 diabetes mellitus,and the difference was statistically significant(P<0.05).There is no significant difference in fasting blood glucose,2 hours postprandial blood glucose,glycated hemoglobin,fasting insulin and 2 hours after meal in the two groups of newly developed type 2 diabetic patients(P>0.05).3.The HBV-DNA positive(>5*10~2 IU/ml)in the observation group was stratified compared with HBV-DNA negative patients(<5*10~2IU/ml),fasting insulin,2 hour postprandial insulin,alanine aminotrans-ferase and aspartate aminotransferase levels in HBV-DNA positive patients were higher than those in HBV-DNA negative patients,the difference was statistically significant(P<0.05).Age,duration of diabetes,duration of HBV infection,body mass index,fasting blood glucose,2hours postprandial blood glucose,fasting C-peptide,2-hour postprandial C-peptide,glycated hemoglobin,total bilirubin,direct bilirubin and globulin between HBV-DNA positive and negative patients,there was no statistically significant(P>0.05).Conclusion:1.C-peptide levels in HBV-infected patients with type 2 diabetes are lower than in those without HBV-infected type 2 diabetes,may be associated with direct or indirect damage of HBV to islet cells leading to decreased endogenous insulin secretion.2.Elevated levels of HBV-DNA quantitative and transaminase are associated with high insulin levels,It may be associated with impaired insulin metabolism after hepatocyte damage after HBV infection.