Risk Factors And Efficacy Of Nicorandil On No-reflow Phenomenon In Patients With Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention

Objective:To predict the risk factors of no-reflow phenomenon in patients with acute myocardial infarction after primary percutaneous coronary intervention and efficacy of nicorandil intracoronary injection on no-reflow phenomenon.Methods:Forty-four patients of acute myocardial infarction with no-reflow phenomenon after the emergent PCI in our hospital from October 2016 to December 2017 were collected as the case group.According to the age,gender and random number table,eighty-eight patients of acute myocardial infarction with reflow phenomenon after PCI during the same period were selected as control group.General conditions of 132 patients were recorded: age,gender,time of symptom onset to opening culprit vessel,hypertension history,diabetes history,smoking,TIMI(Thrombolysis in Myocardial Infarction)grade of pre-operation radiography,BMI,TC,TG,LDL,APo AI,APo B,WBC,red blood cells,RDW,neutrophil,lymphocyte and PLT.The general clinical data of case group and control group were compared respectively.Patients with no-reflow phenomenon were conducted intracoronary injection of nicorandil,and then we compared TIMI,c TFC(Corrected TIMI Frame Count),TMPG(Thrombolysis in Myocardial Infarction Myocardial Perfusion Grading)as well as elevation of ST-segment in the surface electrocardiograph.SPSS22.0 software was adopted to analyze and observe the risk factors of the no-reflow phenomenon in patients with acute myocardial infarction and the efficacy of nicorandil coronary injection on recovery of no-reflow phenomenon.Results: 1.No-reflow phenomenon in patients with AMI after the emergent PCI was significantly related to the time of symptom onset to opening culprit vessel,TC,RDW-CV,BMI,LYM/NEUT,LYM and NEUT by Logistic analysis(P<0.05).2.For the patients with no-reflow phenomenon,TIMI and TMP blood flow grades were improved(P<0.05),and frames of c TFC decreased significantly after intracoronay injection of Nicorandil(P<0.05).Conclusions: 1.The time from symptom onset to culprit vessel opening,TC,BMI,LYM/NEUT are independent risk factors for the occurrence of no-reflow phenomenon after PCI.2.Nicorandil can significantly improve the no-reflow phenomenon of AMI patients during the PCI.