Clinical Significance Of Eosinophil Changes In Patients With Ulcerative Colitis

Research background and Purpose:Eosinophilic granulocyte is a granulocyte derived from bone marrow and plays an important role in the innate immunity of mucosa through various cellular mechanisms.Eosinophils can regulate the immune system by promoting inflammatory mediatorssuchasprostaglandin,leukotriene,cytokines,andantigen presentation.Inflammatory bowel disease?IBD?includes ulcerative colitis?UC?and crohn's disease?CD?,and it is a chronic and permanent inflammation of the gastrointestinal tract disease,mediated by a variety of immune cells,including neutrophils,plasma cells,and eosinophils.The relationship between IBD and eosinophil levels has been studied for more than 50 years.Eosinophils are mainly associated with UC.However,the exact function of eosinophils in UC is still being debated.In this study,we analyzed the EG in the blood and colonic mucosa of UC patients.And we understood the relationship between EG and the general situation and the disease related indicators in UC patients,so as to clarify the clinical significance of EG in UC.Materials and Methods:A total of 182 patients with ulcerative colitis diagnosed in the first hospital of jilin university from January 2013 to December 2017 were selected as the subjects.Inclusion criteria:According to the Chinese medical association digestion neurology inflammatory bowel epidemiology group of“the inflammatory bowel disease diagnosis and treatment of the consensus of opinion"^[1]in 2012 of the diagnosis standard of ulcerative colitis patients diagnosed with ulcerative colitis.Exclusion criteria:patients with parasitic infection andhypereosinophilic syndrome were excluded.Grouping:the patients with elevated blood eosinophil count or pathological biopsy eosinophil infiltration acted as Group A,patients with neither elevated blood eosinophil count,nor pathological biopsy eosinophil infiltration acted as Group B.Baseline patient demographic data,comorbid conditions,time of onset of illness,lesion range,history of digestive system surgery?as to December 2017?,the degree of disease activity evaluation and UC treatment were collected.Then statistical analysis was performed.Results:1?The average level of hsCRP and ESR in the Group A was higher than that in the Group B,and the difference was statistically significant?P<0.05?.After correlation analysis,hsCRP and ESR were positively correlated with EG,with correlation coefficients of 0.161 and 0.184 respectively,and P<0.05.2?The onset time of the Group A was more than that of the Group B?P<0.05?,and the difference between the two groups in the history of digestive system surgery was statistically significant?c²=3.933,P=0.047?.3?Comorbid conditions of UC are liver disease,hypertension and rheumatic diseases.There were differences between the two groups in liver disease and rheumatic diseases?P<0.05?.4?The prevalence of allergy in the Group A was 23.9%,compared with 11%in the Group B.The difference between two groups in the history of allergy was statistically significant?c²=4.660,P<0.05?.In conclusion:1?1,UC patients with increased eosinophils,including elevated blood eosinophils and infiltration of the colonic mucosa,consider the existence of disease activity.2?Comorbid conditions of UC are liver disease,hypertension and rheumatic diseases.UC patients coexisting with liver diseases and rheumatic diseases are more likely to have increased blood eosinophil count and histopathological eosinophil infiltration.3?The incidence of digestive system surgery is higher in patients with increased eosinophil UC,and the patients should be treated more actively.