| Objectives By measuring the level of iodine nutrition and related factors in subclinical hypothyroidism in early pregnancy,to investigate the risk factors associated with subclinical hypothyroidism in early pregnancy,and to provide reference for the screening of subclinical hypothyroidism in early pregnancy.Methods 1 A total of 83 pregnant women with subclinical hypothyroidism who were routinely examined at an obstetric clinic and endocrinology clinic at North China University of Science and Technology from November 2016 to November 2017 were selected as study subjects.The average gestational age was 8.47±2.03 weeks and the average age was 28.01±3.99 years.Select 55 women with normal thyroid function during the same period of pregnancy as control group,The average gestational age is 8.76±2.09 weeks,the average age is 28.24±3.38 years.The selected subjects were measured for systolic blood pressure(SBP),diastolic blood pressure(DBP),height,initial weight,and their body mass index(BMI),and their serum free triiodothyronine(FT3)levels and free thyroid were measured.Hormone(FT4)levels,Thyroid stimulating hormone(TSH)levels,Thyroid peroxidase antibody(TPOAb),Thyroglobulin antibody(Tg Ab),Urine iodine level,Human chorionic gonadotropin(h CG)concentration,Hemoglobin(Hb)),fasting plasma glucose(FPG),creatinine(Cr),and uric acid(UA)levels.2 Statistical method:Application spss17.0 statistical software,analysis of the relevant data of the research object,Measurement data are expressed as mean ± standard deviation(??±s)or median,P25 and P75,Comparison between two groups using t test or non-parametric test,Count data is expressed in rate(%),using ?2 test.P<0.05 means the difference was statistically significant.Analysis of risk factors in pregnancy with subclinical hypothyroidism,multiple linear linear regression analysis.Results 1 There was no significant difference in gender and age between subclinical hypothyroidism group and normal pregnancy thyroid function group(P>0.05).2 Urine iodine levels in the subclinical hypothyroidism group were higher than those in the normal group.the risk of subclinical hypothyroidism increased 1.7 times in pregnant women with iodine deficiency,The risk of subclinical hypothyroidism in pregnant women increased by 14.2 times in excess of iodine,The risk of subclinical hypothyroidism increased by 29.4 times in pregnant women with excess iodine.3 The BMI of pregnant women in the subclinical hypothyroidism group was higher than that of normal pregnant women.When the BMI was ?24 kg/m2,the risk of subclinical hypothyroidism was approximately 7.4 times higher in pregnant women.4 The blood pressure and FPG of pregnant women in the subclinical hypothyroidism group were higher than those of pregnant women with normal pregnancy thyroid function.5 TPOAb titers were higher in subclinical hypothyroidism than in normal women.When TPOAb >34 U/m L,the risk of subclinical hypothyroidism in pregnant women increased by approximately 3.1 times.6 There was no significant difference in Hb,UA,Cr,Tg Ab,and h CG between pregnant women in the subclinical hypothyroidism group and normal pregnant women(P>0.05).7 Urine iodine level,TPOAb,BMI,SBP,DBP,and FPG were used as independent variables in the regression model,and multivariate logistic regression analysis was performed.The results suggest that urinary iodine level,BMI,TPOAb may be Risk factors for the occurrence of subclinical hypothyroidism in pregnancy.Conclusions 1 Urine iodine level,BMI,TPOAb,SBP,DBP,and FPG levels in early pregnant women with subclinical hypothyroidism were higher than those in normal pregnant women.2 Urinary iodine levels are associated with the occurrence of subclinical hypothyroidism,excess iodine and iodine excess increase the risk of subclinical hypothyroidism in pregnant women.3 The levels of BMI and TPOAb are related to the occurrence of subclinical hypothyroidism.The level of BMI,TPOAb increase,and the risk of pregnant women suffering from subclinical hypothyroidism increases. |
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