Study On Correlation Of AGE And RAGE Levels With GDM And Neonatal Nervous System Development

Objectives To investigate the relationship between the level of advanced glycation end product(AGE)in gestational diabetes mellitus(GDM)maternal elbow vein serum,neonatal umbilical vein serum and its receptor(RAGE)levels,and with the GDM as well as the relationship between the development of early neonatal nervous system.Methods 80 cases of GDM pregnant women were collected as GDM group,and 80 cases of normal glucose tolerance who deliveried in the same period of hospital and had the same gestational age were selected as the control group.The levels of AGE and RAGE in the serum of two groups of maternal elbow veins and neonatal umbilical arteries were detected by ELISA method.The NBNA scores were measured at 72 h after neonatal birth.Analysis of the above indicators.Results 1 The AGE(19.91±13.84?g/ml)and RAGE(328.78±182.43pg/ml)in the maternal serum of group GDM were higher than the AGE(10.84±5.39?g/ml)and RAGE(168.29±161.71pg/ml)in the maternal serum of the control group.The difference was statistically significant(t=5.465,5.888,P<0.05).The AGE(17.79±10.72?g/ml)and RAGE(439.39±311.31pg/ml)in the neonatal umbilical serum of group GDM were higher than the AGE(12.21±6.56?g/ml)and RAGE(273.96±169.02pg/ml)in the neonatal umbilical serum of the control group.The difference was statistically significant(t=3.966,4.177,P<0.05).2 The level of AGE and RAGE in mother blood are related to GDM,The increase of AGE and RAGE levels in the mother blood increases the risk of GDM [OR=4.435,6.556,95% CI: 2.118-9.285,3.287-13.076],The difference was statistically significant(P<0.05).The increase of AGE and RAGE levels in the umbilical cord blood increases the risk of GDM [OR=2.672,2.313,95% CI: 1.376-5.189,1.214-4.407],The difference was statistically significant(P<0.05).AGE and RAGE levels in maternal blood are more closely related to GDM.3 The level of AGE and RAGE in mother blood are related to neonatal behavioral neurological injury,The increase of AGE and RAGE levels in the mother blood increases the risk of neonatal behavioral neurological injury.[OR=9.044,3.742,95% CI: 4.203-19.464,1.937-7.228],The difference was statistically significant(P<0.05).The level of AGE and RAGE in the umbilical cord blood are related to neonatal behavioral neurological injury,The increase of AGE and RAGE levels in the the umbilical cord blood increases the risk of neonatal behavioral neurological injury.[OR=3.071,1.966,95% CI: 1.579-5.972,1.038-3.721],The difference was statistically significant(P<0.05).AGE and RAGE levels in maternal blood are more closely related to neonatal behavioral neurological injury.4 GDM group of neonatal active muscle tension(6.65±1.11score),primitive reflex(5.10±0.54score)and NBNA total score(36.33±1.32score)is lower than the control group in active muscle tension(7.68±0.49score),primitive reflex(5.88±0.38score)and NBNA total score(38.56±0.78score),there was statistical significant differences(t=-7.613,-10.554,-12.990,P<0.05).5 GDM is associated with neonatal behavioral neurological injury,and the risk of behavioral neurological injury in GDM newborns increases[OR=53.747,95% CI: 20.236-142.757,P<0.05],The difference was statistically significant(P<0.05).Conclusions 1 AGE and RAGE levels are associated with GDM,and elevated levels of AGE and RAGE increase the risk of GDM in pregnant women.2 The levels of AGE and RAGE are associated with neurobehavioral impairment in newborns.Increased levels of AGE and RAGE in neonates have an increased risk of behavioral neurological impairment.3 GDM is associated with neurobehavioral impairment in neonates,and GDM neonates have an increased risk of behavioral neurological impairment.