Changes And Significance Of Distribution Of Blood Lipids And LDL Subclass In Pre-eclampsia

Objectives To investigate the changes of blood lipid level and LDL subclass distribution in pre-eclampsia patients and their effects on perinatal outcomes.Methods This study uses a prospective cohort study,from November 2016 to August 2017,58 pregnant women diagnosed as pre-eclampsia in obstetrics department of Hebei Provincial people’s Hospital were selected as pre-eclampsia group,and 53 pregnant women with normal blood pressure due to premature delivery were selected as control group.The general clinical data of two groups of pregnant women were collected and the composition and content of serum lipids and LDL subclass were detected by automatic biochemical analyzer and Lipoprint lipoprotein subclass analysis system.At the same time,the fetal umbilical artery blood flow index was measured by color Doppler ultrasound,and the delivery outcome of the two groups was observed.All the collected data were recorded into Epi Date software and analyzed statistically by SPSS 17.0 software.T test or rank sum test were used to analyze the general clinical data of the two groups,whether there were differences between the blood lipid index and umbilical artery ultrasound blood flow index,and the correlation factors were analyzed by Pearson correlation analysis.Results 1 Comparison of general clinical data,BMI,SBP and DBP in PE group were significantly higher than those in control group(P < 0.05).The weight of newborns in PE group was significantly lower than that in control group(P < 0.05).There was no significant difference in age and gestational weeks between the two groups(P > 0.05).2 Comparison of serum lipids: TG and Atherosclerosis index(AI)in PE group were significantly higher than those in control group(P < 0.05)and the ratio of HDL / LDL and LDL/apo B in PE group was significantly lower than that in control group(P < 0.05).3 Comparison of LDL subclass: LDL1 in PE group was significantly lower than that in control group(P < 0.05),and there was no significant difference between the two groups(P > 0.05).4 Comparison of ultrasound blood flow index of umbilical artery: the UAPI,UA-RI and UA-S/D in PE group was significantly higher than that in control group(P < 0.05).5 TG(r=﹣0.217,P < 0.05),HDL(r=﹣0.309,P < 0.05)and apo A I(r=﹣0.376,P < 0.05)were negatively correlated with the weight of the newborn in PE group,but no correlation between blood lipid index and neonatal weight in control group(P > 0.05).6 LDL(r=0.260,P<0.05),apo B(r=0.281,P<0.05)and AI(r=0.262,P<0.05)was positively correlated with systolic blood pressure in PE group,but there was no correlation between blood lipid index and systolic blood pressure in control group(P > 0.05).7 There was a positive correlation between TG and UA-S/D in PE group(r=0.273,P < 0.05).There was no correlation between control group and UA-S/D(P > 0.05).8 UA-PI(r=﹣0.576,P<0.05),UA-RI(r=﹣0.434,P<0.05)and UA-S/D(r=﹣0.568,P<0.05)were negatively correlated with neonatal body weight and positively correlated with systolic blood pressure in PE group(r=0.549,r=﹣0.611,r=0.518,P<0.05).Conclusions 1 There is obvious abnormal lipid metabolism in pre-eclampsia patients,and the blood lipid tends to cause atherosclerosis,which may be related to the severity of the disease.2 The distribution of LDL subclass changes in PE patients.3 Dyslipidemia in pre-eclampsia is associated with perinatal adverse outcomes.