Relatinship Of The Small, Dense Low-density Lipoprotein With Coronary Heart Disease And The Stenosis Of Coronary Arteries

Background: The increasing of the level of LDL was considered closely related to the development of coronary heart disease. Some studies in recent years showed that one of its sub-components was the small, dense low-density lipoprotein(sdLDL), which atherosclerosis may be more than LDL. There were few studies about the relationship of sdLDL with coronary heart disease and the stenosis of coronary arteries, the results of these studies were still not clear either.Objective: To investigate the relationship of sdLDL with coronary heart disease and the stenosis of coronary arteries.Methods: A total of 106 patients with coronary heart disease diagnosed by coronary angiography were enrolled as the coronary heart disease (CHD)group, which was divided into 3 groups including the stable angina pectoris(SAP) group(34 cases), the unstable angina pectoris(UAP) group(42 cases) and the acute myocardial infarction(AMI) group(30 cases). We chose 30 patients with normal coronary angiography as control group(30 cases). The level of sdLDL was collected as well as other clinical data. The severity of coronary artery stenosis was quantautive1y assessed by Gensini score.Result: The level of sdLDL in CHD group was higher than that in control group (0.657±0.387mmol/L vs. 0.463±0.215mmol/L,P﹤0.05). The levels of sdLDL in SAP group, UAP group and AMI group were significantly higher compared with that in control group(0.657±0.406mmol/L,0.636±0.365mmol/L and 0.680±0.409mmol/L vs. 0.463±0.215mmol/L,P﹤0.05). There was no statistic differences in the level of sdLDL among SAP group, UAP group and AMI group(P﹥0.05).Logistic regression analysis showed that the sdLDL levels were independently associated with coronary heart disease(OR=4.70, 95%CI:1.66～10.23,P﹤0.05). The severity of coronary artery stenosis defined by Gensini score was positively correlated with the sdLDL level in SAP and UAP group(r=0.670, P﹤0.01; r=0.643, P﹤0.01, respectively) but not in AMI group (r=0.295, P﹥0.05).Conclusions: 1.The level of sdLDL was significantly increased in CHD patients including SAP, UAP and AMI patients compared with non-CHD people. It was an important markers in predicting the appearance of CHD. No difference was found in the level of sdLDL among SAP, UAP and AMI patients. 2. The sdLDL level may be an independent risk factor for coronary heart disease. 3. The severity of coronary artery atherosclerosis was positively correlated with the sdLDL level in SAP and UAP patients but not in AMI patients. It could be a judgment indicator of coronary stenosis for patients with angina pectoris.