Relationship Between Seasonal And Coronary Blood Flow Velocity And Related Influencing Factors

Objective: To investigate the difference of blood flow velocity in different seasons of patients with coronary artery stenosis and coronary heart disease(divided into unstable angina and acute ST-segment elevation myocardial infarction)and the effect of seasonal difference on cardiac function.Methods: Continuous enrollment June-August 2016(summer group),December2015-February 2016(winter group)All coronary angiographies at the First Affiliated Hospital of China Medical University showed no obvious epicardial coronary vessels A total of 217 patients with normal and narrow coronary angiography were enrolled in this study,including 104 in the summer group and 113 in the winter group;2016,June-August 2017(summer group),December2015-2016 February and December 2016-February 2017(winter group)All patients with unstable angina undergoing diagnostic imaging of coronary artery angiography showing single anterior descending coronary artery disease who were implanted with a single stent and met the inclusion and exclusion criteria 147 cases of unstable angina pectoris,including 76 cases in summer and 71 cases in winter.All patients with unstable ST-segment elevation myocardial infarction undergoing emergency coronary angiography showed single anterior descending coronary artery disease A total of 104 patients with acute myocardial infarction were enrolled in a single stent and met the inclusion and exclusion criteria,47 in summer and 57 in winter.Coronary artery blood flow frames were recorded by corrected thrombolysis in myocardial infarction flow frame count(cTFC),the cardiac function parameters were accurately measured by Doppler ultrasound,the relationship between seasons and blood flow velocity was clarified,And seasonal effects on heart function.Results: 1.Compared with the summer group,the systolic blood pressure in patients with normal coronary angiography in winter group increased(P<0.01),hematocrit(HCT)increased(P <0.05)and plasma prothrombin time(PT)decreased),Serum uric acid(UA)decreased(P <0.01);HCT increased(P <0.05)and PT decreased in patients with unstable angina pectoris(P<0.05).2.Compared with the summer group,the blood flow velocity of LAD and LCX in winter group was slow(P <0.05),but there was no significant difference in right coronary artery(RCA)Preoperative and postoperative LAD blood flow velocity was slow in patients with angina pectoris(P <0.01);LAD blood flow was slow in patients with acute myocardial infarction(P<0.01).LAD blood flow velocities in patients with acute myocardial infarction were significantly lower than those in patients with unstable angina(<0.001),those in summer(<0.001)and those in patients with unstable angina(all <0.001)Preoperative LAD blood flow velocity compared with no difference.3.Preoperative blood flow velocity was positively correlated with HCT(r = 0.013,P = 0.03)and negatively correlated with PT(r = 0.012,P= 0.04)in patients with normal angina and patients with unstable angina pectoris,There was a positive correlation with UA(r = 0.015,P = 0.03).4.Compared with the summer group,the diameter of left ventricular end-diastolic diameter(P <0.05),A peak increased(P <0.05),E / A decreased(P <0.05).No significant differences were found in patients with unstable angina and acute myocardial infarction.Conclusion: In patients with normal coronary angiography,unstable angina pectoris and acute myocardial infarction,there are seasonal differences in blood flow velocity,slow in winter compared with summer,and blood flow velocity has no relation with the degree of coronary artery stenosis,and the postoperative LAD blood flow in acute myocardial infarction The rate is slower in winter,summer and overall than in patients with unstable angina.