META Analysis Of Clinicopathological Characteristics Of MMR Expression Loss Of Endometrial Cancer

Objective:Through the meta-analysis of the literature about the clinicopathological characteristics of endometrial carcinoma with MMR expression loss in the database in recent years,further clinical recommendations can be obtained to guide the screening of endometrial cancer patients for Lynch syndrome-related screening.Methods:The strategy of searching is to retrieve the data of CNKI,VIP,Wanfang Medical Network,Chinese Biomedical Literature Service System,PUBMED and other databases by using computer to obtain the related literature about the pathological study of endometrial carcinoma with missing MMR from 2007 to2017.Chinese search terms include "endometrial cancer,DNA mismatch repair,pathology",and English search terms include "MMR,DNA mismatch respair,endometrial cancer,endometrial carcinoma,pathology." The search for all the literature through Literature title,abstract,the full text of the preliminary screening.After the initial screening,a total of 28 Chinese literature and 191 English literature were obtained.After strict inclusion and exclusion criteria,5 articles were finally included,all of which were in English.After data extraction of these 5 articles,they were divided into 7 groups: FIGO pathological staging group,differentiation degree group,lymphatic vessel invasion group,tissue type group,myometrial invasion group,tumor location group and synchronous ovarian cancer group.Statistical analysis was performed with Review Manager 5 to get the statistical indexes of the relationship between MMR expression loss and FIGO pathological stage,differentiation degree,lymphatic vessel invasion,tissue type,myometrial invasion,tumor location and synchronous ovarian cancer.Funnel chart.Results:1?EC with MMR expression loss in stage I-II EC was higher than stage III-IV EC2?MMR expression loss of EC in the high-moderate differentiation was higher than low differentiated3?The incidence of non-lymphovascular infiltration of EC with MMR expression loss was higher than that of EC with lymphovascular infiltration4?There is no proof of the absence of MMR expression of EC and pathological tissue type,myometrial invasion,tumor location and the existence of synchronous ovarian cancer correlationConclusion:The incidence of EC with MMR expression loss in stage I-II was higher than that in stage III-IV,and the incidence of high-moderate differentiation was higher than that of low differentiated,and the incidence of non-lymphovascular infiltration was higher than that of EC with lymphvascular infiltration.Thus,it is recommended that patients with lymphatic infiltrates be highly differentiated and differentiated in early stages of FIGO staging(stage I-II)of EC Recommended pathology Related genetic tests related to Lynch syndrome need a larger sample size supported.