The Efficacy And Safety Of The Drug-Eluting Balloons Used In Treating Femoral-Popliteal Arteriosclerosis Obliteration

Objective: To compare the efficacy and safety of drug-coated balloon with conventional balloon in the treatment of femoropopliteal occlusion.Methods: Forty-two patients with definite diagnosis of femoral arteriosclerosis obliterans were collected,including 28 cases of primary stenotic lesions and 14 cases of occlusive lesions.Randomly divided into experimental group(drug coated balloon)21 cases and control group(ordinary balloon)21cases.Recorded late lumen loss(LLL),minimal lumen diameter(MLD),ankle brachial index(ABI),Rutherford grading,restenosis rate,and clinical adverse events before and 6 months after surgery were recorded in both groups of patients.Results: The preoperative MLD,ABI levels,Rutherford grading,Rutherford grading of 1 week after surger and immediate postoperative MLD were not statistically different between the two groups(P>0.05).The MLD of the experimental group was significantly higher than that of the control group at 6 months postoperatively(P<0.05).LLL was significantly lower than the control group(P<0.05);ABI levels at 1 week and 6 months after surgery were significantly higher in the experimental group than in the control group(P<0.05);3 months after surgery,and surgery There was a statistically significant difference in compo-sition ratios between the two groups after the first 6 months of Rutherford’s classification(P<0.05).The restenosis rate was significantly lower in the experimental group than in the control group at 6months(P<0.05).The adverse events such as amputation and death were included in the experim-ental group.There was no statistical difference between the control group and the control group.Conclusion: Compared with conventional balloons,the drug-coated balloon group in this study can improve ABI and Rutherford grading,effectively reducing the incidence of late lumen loss and restenosis events within 6 months,and did not increase within 6 months.The incidence of adverse events is safe and effective in short-term treatment of femoropopliteal occlusion.