Effects Of Intraoperative Vasoactive Drugs On Postoperative Neurological Complications In Patients Undergoing Off-pump Coronary Artery Bypass Grafting (OPCABG)

Objective:To investigate the effects of vasoactive drugs on postoperative neurological complications in patients undergoing off-pump coronary artery bypass graft（OPCABG）by surgical follow-up.Methods:100 cases of OPCABG patients were selected.According to the vasoactive drugs,they were divided into the treated group（Group D）and the un-treated group（Group N）.The Group D were divided into the norepinephrine group（Group D₁）,the ephedrine group（Group D₂）,and the combined group（Group D₃）.According to the single dose of norepinephrine,theyweredividedinto≥10μg（GroupNE₁）and<10μg（Group NE₂）.Postoperative neurological complications were recorded and conclusions were drawn.Results:1.In the 100 patients,38cases（38.0%）had postoperative neurological complications.2.Of the 100 patients,38 cases（38.0%）were used vasoactive drugs.3.The prevalence of hypertension in the group D and the group N was71.1%and 45.2%,and the postoperative neurological complication rate was55.3%and 27.4%.The difference was statistically significant（P<0.05）.Except for hypertension,the incidence of postoperative neurological complications in the group D was higher than that in the group N.4.There were significant differences in the postoperative neurological complication rate between the group N and the group D₁ or D₃（P<0.05）.The incidence was higher in the group D₁ or in the group D₃ than in the group N.There was no significant difference in the postoperative neurological complication rate between the group N and the group D₂（P>0.05）.5.There was no significant difference in the postoperative neurological complication rate between the group D₁ and the group D₃（P>0.05）.6.There were significant differences in the postoperative neurological complication rate between the group NE₁ and the group N or NE₂（P<0.05）.The incidence of postoperative neurological complications in group NE₁ was higher than that in the group N or the group NE₂.There was no significant difference in the postoperative neurological complication rate between the group NE₂ and the group N（P>0.05）.Conclusions:1.Compared with the un-treated group,the use of ephedrine during surgery doesn’t increase the incidence of postoperative neurological complications.2.Compared with the un-treated group,intraoperative use of norepinephrine with a single dose≥10μg increases the incidence of postoperative neurological complications.