The Clinical Effect Observation Of Chinese Herbal Medicine For Nourishing Yin And Purging Fire Treating Girls With Idiopathic Central Precocious Puberty(Pattern Of Yin Deficiency With Effulgent Fire Syndrome)

Objective:To observe the clinical curative effect of Chinese herbal medicine for nourishing Yin and purging Fire in treating girls with idiopathic central precocious puberty.Preliminary discussion on the availability and safety of Chinese herbal medicine for nourishing Yin and purging Fire.Methods:Sixty-four cases of western medicine were selected as idiopathic central precocious puberty,Chinese medicine diagnosis of precocious puberty,dialectical pattern of yin deficiency with effulgent fire Syndrome;,aged 4-8 years old children as the object of study,were control divided into two groups,the treatment group of 32 cases,the control group of 32 cases.The treatment group was given oral Chinese herbal medicine for nourishing Yin and purging Fire(4-5 years old 80 ml po tid,6-8 years old 100 ml po tid).The control group was treated with western medicine:intramuscular injection of leucolillin microspheres,Initial dose of 90ug/kg for every 4 weeks,the maximum dose of 3.75 mg.The course of treatment is 3 months,continuous treatment 2 courses.Curative effect evaluation of the total curative effect and the observation indexes before and after treatment of integral within the group,the comparison between the groups.The efficacy of SPSS20.0 was used to analyze the results of the two groups of children before and after treatment,the final evaluation of the clinical efficacy and Clinical economic significance of Chinese herbal medicine for nourishing Yin and purging Fire.Result:This test was included in 64 cases that met the criteria,the treatment group 32 cases,the control group 32 cases,the treatment group fell out in the course of 2 cases,the final treatment group was 30,and the control group was 32 cases.1?Disease curative effect comparison: the treatment group total effectiveness 63%,the control group total effective rate 88%,total effective rate compared two groups,P < 0.05,the difference was statistically significant.2?Comparison of TCM syndromes: in the improvement of major symptoms,the two groups were compared with P < 0.05,and the difference was statistically significant.In the improvement of secondary symptoms,the two groups were compared,P < 0.05,and the difference was statistically significant.The total effective rate of TCM syndromes in the treatment group was 70%,and the total effective rate of the control group was 81%,and the difference between the two was not statistically significant.3?After treatment,the treatment group in serum hormone levels,ovaries,uterus volume,diameter on the previous did not see improved significantly,P > 0.05,there was no statistically significant difference;The control group was significantly improved,P < 0.05,and the difference was statistically significant.4?After treatment,the treatment group BA/CA ratio of the previous did not see obvious drop,P > 0.05,there was no statistically significant difference;The control group decreased significantly,P < 0.05,and the difference was statistically significant.The growth rate of the treatment group was significantly higher than that in the control group(P < 0.05).5?In terms of cost-effectiveness analysis,the treatment group and the control group had lower cost,which was more suitable for China's national conditions and had better clinical economic significance.6?No clinical adverse events occurred in the treatment group and the control group.Conclusion:Chinese herbal medicine for nourishing Yin and purging Fire is the treatment of childhood idiopathic central precocious puberty pattern of yin deficiency with effulgent fire Syndrome;the effective prescription,and In the process of the research found no clinical adverse events,It has a better clinical economic significance,and it offers another option for children's idiopathic central precocious treatment.