Study On The Relationship Between The Outcome Of Miscarriage Prevention And TCM Syndrome And Endocrine Function In 690 Cases With Early Threatened Abortion

Objective:1.Preliminary study on the relationship between placenta outcome and TCM Syndrome Type in patients with early threatened abortion,To provide basis for clinical treatment of TCM syndrome differentiation and prediction of pregnancy outcome,and to better guide clinical drug use.To analyze the correlation between placenta outcome and endocrine?Thyroid function?insulin function?status in patients with early threatened abortion.To explore the effect of endocrine condition on the outcome of early threatened abortion.To provide data support for early intervention of endocrine and medication.Method:Application of retrospective method,we collected data of patients who were diagnosed as early threatened abortion in gynecological department of affiliated hospital of Chengdu University of traditional Chinese Medicine From June 2014 to December 2017,690 cases determined by inclusion,exclusion and exclusion criteria,According to the outcome,515 cases were divided into two groups:successful group?515 cases?and failed group?175 cases?.The age,history of pregnancy and delivery,menstruation,history of ovarian surgery and thyroid function,insulin function,the level of hCG?PE ₂?P at 4-10 weeks of gestation,and TCM syndromes,fetal heart,embryo,and so on were collected.Among them 532 cases of thyroid function examination and 310 cases of islet function examination were collected.Enter valid data into the excel,Statistics of data by spss24.0 Statistical Software?Results:1.Among 690 patients with early threatened abortion,515 cases?74.6%?were in the successful group and 175 cases?25.4%?in the failed group.2.690 patients with early threatened abortion,age and menarche age had a significant effect on the outcome of antepartum,and the failure rate was significantly higher in the patients over 35 years old than 35 years old,and the failure rate in the patients with menarche age of 16 years or older.There was no significant difference in menstrual cycle and menstrual volume between the two groups?P>0.05?.3.690 patients with early threatened abortion,The total pregnancy,the number of spontaneous abortion,and the number of induced abortion had an effect on the outcome of placenta?P<0.05?.There was no significant effect on the outcomes of the patients in the two groups,such as the total labor times,the times of drug flow,the times of preterm delivery,the times of induced labor and the times of ectopic pregnancy..4.Among the 690 patients with early threatened abortion,the difference in serum E2 level between the two groups of pregnant 4¹0 weeks was statistically significant?p<0.05?.There was a significant difference in the level of serum hCG in the two groups of pregnant 7¹0 weeks?p<0.05?.5.A total of 310 cases of pancreatic islet function examination were received in this study.The islet function was normal in 147 cases and insulin resistance or hyperinsulinemia in 163 cases?62.6%?.There was no significant difference in fasting blood glucose and fasting insulin between the two groups?P>0.05?.There were 26patients who were treated with metformin according to the advice of endocrine department.This study found that whether metformin treatment had an effect on the outcome of fetus?p<0.05?.6.In this study,532 cases of thyroid function test were collected in 690 patients with early threatened abortion,Among them,223 cases had normal thyroid function,299 cases had hypothyroidism,and 10 cases had hyperthyroidism.After treatment,the thyroid function had no significant effect on the outcome of the fetus?p>0.05?,and there was a significant difference between the two groups in the level of tsh?p<0.05?.133 cases were treated with Utrel according to the advice of Endocrinology,including105 cases in the successful group and 28 cases in the failed group.There was no significant difference in the outcome of hypothyroidism therapy?P>0.05?.7.Of the 690 cases of early threatened abortion,there were 484 cases of kidney deficiency syndrome?70.1%?,96 cases of spleen and kidney deficiency syndrome?13.9%?,82 cases of kidney deficiency and blood stasis syndrome?11.9%?,27 cases of blood heat syndrome?3.9%?and 1 case of Qi and blood deficiency syndrome?0.1%?.8.In this study,690 cases of early threatened abortion cases,comparison of TCM syndrome type tocolysis success group and failure tocolysis group,the difference was statistically significant?P<0.05?.A further 22:kidney deficiency and blood heat syndrome,kidney deficiency and spleen kidney two empty,blood heat syndrome and spleen and kidney deficiency syndrome two,no significant blood heat syndrome and the difference between kidney deficiency and blood stasis syndrome?P>0.05?.Kidney deficiency and blood stasis syndrome,two spleen and kidney deficiency syndrome and kidney deficiency and blood stasis syndrome between the two groups in the outcome of tocolysis was statistically significant?P<0.05?.Conclusion:1.This study preliminarily showed that the distribution of TCM syndromes was mainly kidney deficiency syndrome,and TCM syndrome type had influence on early threatened abortion outcome.The pregnancy failure rate of patients with kidney deficiency and blood stasis syndrome was higher than that of kidney deficiency syndrome and spleen and kidney deficiency syndrome.2.This study preliminarily showed that early threatened abortion with thyroid dysfunction was more common in hypothyroidism.The pregnancy outcome of hypothyroidism patients treated by endocrine department was not significantly different from that of normal group.Whether or not patients with hypothyroidism were treated with euthyroidism had no significant effect on the outcome of the fetus.3.In this study,the effect of islet function on early threatened abortion outcome was not significant.Whether or not patients with insulin resistance are treated with metformin has an effect on the outcome of the fetus.4.In this study,age is one of the high risk factors affecting the outcome of the fetus,and menarche age is one of the factors affecting the outcome of the fetus.Total pregnancy,spontaneous abortion,induced abortion times have an impact on the outcome of the fetus.