Study On The Relationship Between Abortion Outcome And Sex Hormone And TCM Syndrome Types In 124 Patients With Early Threatened Abortion

Objectives:1.Objective to investigate the monitoring of serum sex hormones(E2,P,hCG)in patients with early threatened abortion-β)The relationship between gestational sac,fetal bud,fetal heart rate and pregnancy outcome after tocolysis treatment was examined by color Doppler ultrasound at 6-9 weeks of pregnancy.To predict the outcome of pregnancy,avoid blind abortion.2.Objective to explore the distribution of TCM Syndrome Types in patients with early threatened abortion,and to provide data support for TCM syndrome differentiation and treatment of the disease.Methodology:A retrospective study was conducted to collect the data of 124 patients with Early Threatened Abortion who were hospitalized in the Department of Gynecology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(Sichuan Hospital of Traditional Chinese Medicine)from January 2018 to December 2019.According to the inclusion,exclusion and exclusion criteria,the subjects were divided into two groups: 95 cases in the successful group and 29 cases in the failure group.The age,menstruation,history of pregnancy and childbirth,history of intrauterine operation,fetal heart rate,TCM syndrome type,E2 level at 5~9 weeks of pregnancy,gestational sac and embryo were collected.The data were entered into excel and analyzed by SPSS 26.0.Results:1.Among 124 cases of early threatened abortion,95 cases(76.6%)were in the successful group and 29 cases(23.4%)were in the failure group.2.The success rate of early threatened abortion patients aged 42 years or above decreased significantly(P < 0.05).Pregnant women with thin body mass index were more likely to have abortion failure(P < 0.05).There was no significant effect on the outcome of abortion whether to work during pregnancy,total times of pregnancy,total times of labor,spontaneous abortion,adverse pregnancy,intrauterine operation,times of induced abortion and normal menstruation before pregnancy(P > 0.05)3.In the early threatened abortion group,the serum estradiol(E2),progesterone(P)and h CG levels were significantly higher than those in the successful abortion group-β The difference was statistically significant(P < 0.05).Serum estradiol(E2)can predict the prognosis of early threatened abortion.The serum E2 concentration is higher and increases steadily with gestational age.If the estradiol level is higher than 563.30 pg/ml at 7 weeks of pregnancy,it indicates that the prognosis of early threatened abortion is good after tocolysis.Serum progesterone(P)is one of the important indicators to predict the outcome of early pregnancy.The concentration of serum P remains stable in early pregnancy,and the level of progesterone at 8 weeks of pregnancy is more than 27.27 ng / ml,which indicates that the prognosis of early threatened abortion is good.Serum h CG-β It can predict the pregnancy outcome of early threatened abortion,and the serum h CG of 5-8 weeks of pregnancy-β The serum h CG of 8 weeks of gestation increased steadily-β The level > 64475.00 m IU / ml indicated that the patient had a high probability of successful pregnancy after treatment.4.Gestational sac and embryo bud increased with gestational age at 8 weeks and 9 weeks,and the visible rate of fetal heart increased at 7 weeks,8 weeks and 9 weeks,the difference was statistically significant(P < 0.05).The gestational sac and embryo bud increased with the increase of gestational age at 8 weeks and 9 weeks,which indicated that the prognosis was better and the success rate of tocolysis was high.The visible rate of fetal heart increased at 7 weeks,8 weeks and 9 weeks of gestation in the successful group,but decreased in the failure group,and it became 0.0% at 9 weeks of gestation in the failure group,It shows that gestational sac,fetal bud and fetal heart rate at 7 weeks,8 weeks and 9 weeks of pregnancy are of great significance to predict the outcome of euthanasia pregnancy.5.In 124 cases of early threatened abortion,the kidney deficiency syndrome was the most frequent,and there was no statistical significance between the failure group and the success group.Conclusion:1.Age is one of the influencing factors of the outcome of abortion,and the success rate of abortion at the age of 42 or above decreased significantly2.Serum estradiol(E2),progesterone(P),HCG-β It can predict the prognosis of early threatened abortion.If the serum E2 level at 7 weeks of pregnancy is more than 563.30 pg / ml,the serum P level at 8 weeks of gestation is more than 27.27 ng / ml and the serum HCG-β level at 8 weeks of gestation is more than 64475.00 m IU / ml which are suggested that the prognosis of early threatened abortion is good.3.Gestational sac,fetal bud and fetal heart rate at 6-9 gestational weeks are of great significance in predicting the outcome of euthanasia.4.The distribution of TCM syndrome types of early threatened abortion patients(fetal leakage and fetal restlessness)is mainly kidney deficiency syndrome,followed by spleen and kidney deficiency syndrome > blood heat syndrome > Qi and blood deficiency syndrome > kidney deficiency and blood stasis syndrome.Different TCM syndrome types have no significant effect on the outcome of abortion.