The Value Of Serum Trace Elements In The Diagnosis And Pathological Classification Of Prostate Cancer

Objective:The levels of zinc(Zn),copper(Cu),calcium(Ca),magnesium(Mg)and iron(Fe)in serum of patients with prostate cancer and benign prostatic hyperplasia were determined,to explore the value of trace elements in the diagnosis and pathological grade of prostate cancer,and provide scientific basis for the diagnosis,treatment and evaluation of the prognosis of trace elements in prostate cancer.Methods:Randomly selected 32 patients with prostate cancer(PCa)who were hospitalized in the Department of Urology of the First Hospital of Shanxi Medical University First Clinical Medical College from April 2017 to December 2017 as the experimental group,72 patients with benign prostatic hyperplasia(BPH)in the same period as control group,to take venous blood 2-5ml,the content of Zn,Cu,Ca,Mg and Fe in serum was detected by Inductively Coupled Plasma Mass Spectrometryatomic.SPSS20.0 statistical software was used for statistical analysis.The measurement data satisfied the normality and homogeneity of variance,and independent sample t-tes was used,In the mean ±standard deviation format,analysis of differences in the incidence of count data,the use of chi-square test.Variables with single factor tests were included in the multivariate logistic regression model,the serum levels of trace elements in patients with PCa and BPH were compared and the influencing factors were compared.Using Pearson correlation analysis method,P<0.05 was considered statistically significant,the relationship between serum trace elements and pathological grade in PCa patients wasanalyzed.Results:Of the 104 testers,32 were diagnosed as having prostate cancer and 72 as benign prostatic hyperplasia.Statistical analysis showed that age,Cu,Zn,Mg,Fe,and Ca/Mg were statistically significant(p<0.05).Comparing with patients with BPH,the serum Cu,Fe and Ca/Mg ratios in patients with PCa were higher than those in BPH group,and the levels of Mg and Zn were lower than those in BPH group.There was no significant difference in other factors.The univariate test meaningful variables were included in the multivariate logistic regression model.After the multivariate logistic regression model was used to control other variables,the probability of suffering from PCa was 1.207 times higher than that of BPH when one unit of Cu was added;and Fe was 1.893times;In the case of controlling other variables,exp(b)of Mg = 0.003(or <1),and Cu and Fe are risk factors for PCa;Mg is a protective factor for PCa.In 32 patients with PCa,Pearson correlation analysis was performed with Zn,Cu,Ca,Mg,Fe and Gleason scores.It was found that serum Fe levels in patients with PCa were positively correlated with Gleason scores,while negative correlations were found between Zn levels and Gleason scores..Conclusion:1.Detection of serum trace elements can help diagnose prostate cancer;2.The increase of Fe and Cu and the decrease of Mg may be related to the occurrence of prostate cancer;3.For prostate cancer patients the levels of Zn and Fe are related to the pathological grade of prostate cancer.The higher the pathological grade of prostate cancer,the higher the level of Fe and the lower the level of Zn,the detection of serum trace elements has certain reference value for the evaluation of the prognosis of prostate cancer.