Relationship Between Serum Cystatin C,High Sensitive C-reactive Protein And Carotid Intima-media Thickness In Populations Of Different Glucose Tolerance

Objective:To investigate the changes of serum cystatin C(Cys C)and high sensitive C-reactive protein(hs-CRP)levels in different glucose tolerance patients,as well as the associations of these changes with the index of carotid intima-media thickness(IMT).Methods:One hundred and fifty people were divided into 3 groups including normal glucose tolerance group(group NGT,n=30),impaired glucose tolerance group(group IGT,n=60)and newly diagnosed type 2 diabetes mellitus group(group T2DM,n=60).Using latex particle enhanced turbidimetric method to measure the serum levels of Cys C,using immunoturbidimetry to detect hs-CRP levels,using ultrasound to measure carotid IMT,and using high performance liquid chromatography method to measure glycosylated hemoglobin(HbAlc)levels in 3 groups.Fasting serum insulin(FINS)was detected by chemiluminescence immune assay,fasting plasma glucose(FPG)and biochemical indexes were measured by full automatic biochemical analyzer,and insulin resistance index(HOMA-IR)was calculated by the homeostasis model assessment method.Results:?Serum Cys C levels and carotid IMT were increased gradually in the order of NGT,IGT and T2DM patients,with significant differences between any two groups(p<0.05).?The results of multiple linear regression showed that correlations were found between carotid IMT and low densith lipoprotein(LDL-C)(?=0.127,p<0.05),Cys C(?=0.778,p<0.01)and hs-CRP(?=0.339,p<0.01).There was also correlation between Cys C and body mass index(BMI)(?=0.144,p<0.01),HOMA-IR(?=0.197,p<0.01)and hs-CRP(?=1.282,p<0.01).?Carotid atherosclerosis was defined as the carotid IMT was greater than 0.9mm,while normal was defined as the carotid IMT was less than 0.9mm.The dependent variable was defined as whether carotid atherosclerosis or not,wherease independent variable was defined as age,sexuality,BMI,HOMA-IR,fasting plasma glucose(FPG),2h postprandial plasma glucose(2hPG),HbAlc,total cholesterol(TC),trilaurate glycerin(TG),LDL-C,high densith lipoprotein(HDL-C),systolic pressure,diastolic pressure,serum Cys C and hs-CRP.Multiple logistic regression analysis showed that serum Cys C,HOMA-IR,hs-CRP and LDL-C(OR=1.433,4.235,2.531 and 1.339,P<0,05)were independently associated with carotid atherosclerosis.Conclusion:Impaired glucose tolerance patients have high levels of serum Cys C and hs-CRP.Cys C and hs-CRP plays an important role of diabetic arteriosclerosis during its progression.