Meta Analysis Of Efficacy And Safety Of Low Molecular Weight Heparins And Aspirin Therapy On Transient Ischemic Attack

Objective system evaluation of low molecular weight heparin and aspirin therapy transient ischemic attack efficacy and safety.Methods the computer retrieval PubMed(1966?2011.05),EMbase(1974?2011.05),Cochrane library(until 2011,no.3),China biomedical document database(CBM,from 1978 to 2011.05),China journal full-text database CNKI(1994-2011.05),Chinese science and technology journal full-text database(VIP,1989 to 2011.05)access to relevant randomized controlled trial.According to the Cochrane system evaluation method to evaluate the quality of included in the study and use of the Cochrane provide RevMan4.2.8 software were statistically analyzed.Results This study finally into 11 randomized controlled trials,total 731 patients.Fixed effects model results show the total rate of meta-analysis merger effect quantity OR = 4.93,95%CI 2.85to8.55.quantity inspection(Z=5.69,P<= 0.00001)indicates that low molecular heparin group and aspirin group total effectiveness difference was statistically significant;Deterioration rate of Meta analysis showed the difference was statistically significant[R=0.22,95%CI(0.11,0.45),P<0.00001].Security,low molecular weight heparin group reported 27 cases occur skin ecchymosis,8 cases occur gum bleeds,but did not affect treatment process.Conclusions Low molecular weight heparin treatment transient ischemic attack the total effective than aspirin group,low molecular weight heparin treatment transient ischemic attack the deterioration rates lower than aspirin group.Since the system evaluation in the literature with low quality,quantity is less,and some literature small number of cases so still need to do more reasonable design,the implementation of strict multicenter large sample of randomized controlled trials verify this conclusion.Objective:To study the risk factors for transient ischemic attack.Methods:All the study cases of hospitalized patients diagnosed with transient ischemic attack in the Second hospital of Lanzhou University from January 1st,2006 to January 2012,1st totally 160,all cases randomly selected from the corresponding age-off people without TIA 80.The cases detailed records of their clinical data,age 42 to 92 years,an average of 73.61±8.959.To collect data,make corresponding consolidation,patients with disease as dependent variable(Y).age,gender,smoking,alcohol consumption,hypertension,diabetes,hyperlipidemia,and other factors as independent variables(X1-X22),statistical software SPSS17.0 version will collect data with all the overall frequency said(a chi-square test),first conducted univariate analysis to identify the pathogenesis variable,and then multivariate unconditional logistic regression analysis,the regression the equation to determine the risk factors for transient ischemic attack.Results:This study through collecting the data of Logistic regression analysis cases,a regression equations show ischemic attack risk factors to facilitate the primary prevention and secondary prevention of the disease.