| Objective:Discussion cystatin C,interleukin-6 in diabetic nephropathy clinical significance of early diagnosis and treatment.Methods:Select the type 2 diabetic patients clinically diagnosed 70 cases were divided into diabetic patients without nephropathy(DM group)and diabetic nephropathy(DN group),and 30 healthy control group.Were measured in serum interleukin-6(IL-6),cystatin C(CysC),β2-microglobulin((32-MG),blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA)levels and glycosylated hemoglobin levels.Results:①DN significantly higher serum CysC DM group and the control group(t = 2.0715,P<0.05;t = 2.2686,P<0.05),serum CysC was no significant difference compared with the control group between DM(t = 0.3467,P>0.05)② DN serum IL-6 were significantly higher than DM group and the control group(t = 2.3445,P<0.05;t = 5,7204,P<0.001),DM serum IL-6 was significantly higher(t = 2.0864,P<0.05).③The positive rate of serum CysC DN DM group were significantly higher than the control group(χ2 = 33.545,P<0.0001).DM group compared with the control group,DN group blood β2-MG,BUN,Cr,UA result is slightly higher,but not statistically significant difference in the positive rate(P>0.05).④ Serum IL-6 levels and glycosylated hemoglobin levels in patients with diabetes showed a significant positive correlation..Conclusion:①Serum CysC,levels of IL-6 and DN occurrence and development are closely related,DN joint detection can improve the diagnostic sensitivity,serum CysC,levels of IL-6 can effectively reflect the degree of renal injury was,for the clinical treatment of a certain significance.②Blood β2-MG,BUN,Cr,UA examination of DN diagnosis is not sensitive enough,but it may reflect the patient’s condition,and can be used to monitor the efficacy of treatment patients.③Effective control of blood glucose levels in diabetic patients can reduce the incidence of renal injury. |
PDF Full Text Request