The Clinical Analysis Of The Endovascular Stents And Clinical Assays For Symptomatic Intracranial Artery Stenosis

Objective:To assess the safety and clinical efficacy(short-term,mid-term,long-term)of stenting for patients with the best medical treatment in order to assess the efficacy of stenting for symptomatic intracranial artery stenosis.Method:From October 2005 to December 2012,78 patients(78 stenoses)were treated by stent-assisted Angioplasty(SAA)in The First Affiliated Hospital of Dalian Medical University.The information of all in-patients includes:MRI,MRA,DSA et al.and the records of operational procedure and the follow-up information.First all patients compare NIHSS pre-operation with of post-operation,and wingspan study,and the longest follow-up time,we find out the efficacy of SAA.To analysis DSA for pre-operation and post-operation,er find the difference of the arterial diameter at two different times..Restenosis was defined as diameter stenosis>50%in the in-segment area(including the sent area an 5-mm segments proximal and distal to the sent edges).To analysis the location,morphology,diameter of the criminal artery,degree of stenosis,length of stenosis,having or not having plaque et al.we discuss the angiospastic classifications and mechanism of perforator stroke.Result:The average degrees of stenosis of pre-operation and post-operation were 79.23±9.08%and 11.16±18.04%(P<0.05).12patients had major stroke,and one died from rupture of MCA in 30 days.Rates of death and stroke in SAA group were lower than in WASID(P<0.05).The degree of stenosis post operation is lower than Wingspan study.Conclusion:SAA is an efficient technique for treating symptomatic intracranial artery stenosis and preventing ischemic stroke.Death and stroke rates were lower of perioperative time.Long-term follow-up showed the risk of recurrent stoke were lower.Incidence of overall efficacy end point is less than the drug therapy group.Objective:To compare with difference between the patients with intracranial artery stenoses and the patients with extracranial artery stenoses.Methods:81 inpatients with cerebral-arterial stenoses that have been treated in The First Affiliated Hospital of Dalian Medical University.From October 2005 to December 2012 are enrolled in this study.The assays include serum lipid(total serum cholesterol&LDL),CRP,ESR,Uric Acid and RF.30patiens have intracranial artery stenoses.Two groups are compared with all of above factors.We try find out some special factors which can be used to indentify the patients with intracranial artery stenosis.Results:After comparison of all factors,there were no significantly different between two group patients.The mean volume of CRP of extracranial stenosis patients was higher than that of intracranial stenosis patients(5.90±7.96mmol/L vs.3.91±3.56mmol/L),but there was no statistical significance(P=0.209),the same as TC.ESR of extracranial stenosis was lower than that of intracranial stenosis,and also there was no statistical significance(P>0.05)?CRP of 79.01%patients is superior to 3.0mg/L,and it means CRP is a dangerous factor.CRP was higher in cerebral arterial stenosis patients.There was no significant difference between two groups of the rate of the abnormality in clinical assays.The average age of intracranial stenosis patients is younger than extracranial stenosis patients,but there is no statistical significance.Conclusion:CRP was elvated in patients with cerebral arterial stenoses patients.