Expression And Significance Of Platelet-type 12-Lipoxygenase In Low-and High-grade Astrocytoma

Objective:The aim of this study was to determine the expression of P12-LOX in astrocytoma and assess its clinical significance,providing a theoretical basis for clinical diagnosis and treatment.Methods:A retrospective study was performed on 51 patients hospitalized with astrocytoma.We examined the expression levels of P12-LOX in astrocytoma tissue by immunohistochemistry and collected the patient's clinical data and follow-up information.Results:In the present study,we found that P12-LOX was upregulated in astrocytoma samples compared with normal brain tissues and was associated with pathological grade(P<0.01).We measured the AOD value in all 63 cases using the image analysis software Image-Pro Plus 6.0.A significant difference was detected in the mean density of P12-LOX between high-and low-grade astrocytoma,and both grades were significantly different from normal brain tissue.In high-grade astrocytoma,33(94.3%)cases had strongly positive expression,while only 2(5.7%)cases were weakly positive.However,in the low-grade group,14(87.5%)cases were weakly positive,while only 2(12.5%)cases showed strongly positive expression.The difference between the levels was statistically significant(?~2=30.4,P<0.001).The median survival time after surgery was21.9±13.7 months in the group weakly positive for P12-LOX and only 13.4±7.8 months in the group strongly positive for P12-LOX expression(P<0.05).Conclusion:P12-LOX is differentially expressed in low-and high-grade astrocytomas and is associated with survival.