Clinical Efficacy And Safety Of Benvitimod Cream In The Treatment Of Mild And Moderate Psoriasis Vulgaris

Purpose :To study the efficacy and safety of Benvitimod cream in the treatment of mild to moderate psoriasis vulgaris.Methods :The study was included 50 subjects.Patients were randomly divided into 3 groups in a proportion of 2:1:1,which utilizing 1% Benvitimod cream,ositive control drug Calcipotriol ointment and Placebo respectively.Treatments were taken every morning and evening for 12 weeks.The integration data was analyzed by SPSS21.0 software.Results : A.The clinical efficacy: a)the three groups of subjects for 12 weeks PASI response rates(PASI 75)were as follows: Placebo group 30%,Benvitimod group 55.6%,Calcipotriol group 41.7%.Benvitimod > Calcipotriol> Placebo.The results of x-column test showed that there was no statistically significant difference in PASI response rate at 12 weeks of treatment between the three groups(P>0.05).There was no statistically significant difference between the two groups(P>0.0167).b)The PGA response rate(PGA)was 40% in the Placebo group,50% in the Benvitimod group and 66.7% in the Calcipotriol group.Calcipotriol>Benvitimod > Placebo.The results of row-column test showed no statistical difference between the three groups(P>0.05).There was no statistically significant difference between the two groups(P>0.0167).B.The adverse events: the main adverse events for the treatment of folliculitis,local dermatitis,medication itching discomfort.Placebo group 38.5%,Benvitimod group 56.5%,Calcipotriol group 21.4%,Benvitimod > Placebo > Calcipotriol.Conclusion : Completed after 12 weeks of treatment,Benvitimod group,Calcipotriol group and the Placebo group compared with the baseline,the groups of PASI score and PGA scores were significantly lower,initial prompt: The Benvitimod group and the Carbopol group had similar efficacy,both of which were better than the Placebo group.The security:Did not see the skin system during the course of treatment of adverse events,were the skin tissue reaction,belonged to the mild adverse events,with no serious adverse events,the main laboratory tests were not present with clinical significance of abnormal changes,with no deaths in the study,preliminary tip: It was safe,However,because this experiment belonged to the sub-center experiment,the sample size was relatively small,and its security needs to be expanded to further study and discuss.