| Objective:To study the relationship between perineural invasion and prognosis of patients with esophageal cancer.(ESCC).Methods:Retrospective analysis of the clinical pathological data and perineural invasion status of 162 patients with esophageal squamous carcinoma,single factor and multifactor analysis of the relationship between perineural invasion and prognosis.Kaplan-meier method was used to compare the differences in the survival of neuroinvasive patients.Results : The study found that about 19.7%(32/162)of patients had tumor neuropathy.Neuroinvasion was associated with tumor infiltration depth(P= 0.003),which was associated with postoperative staging(P= 0.007).There was no significant correlation with other clinical pathological features(age,sex,tumor site,tumor differentiation degree,lymph node metastasis)(P >0.05).The 5-year disease-free survival rate was significantly lower than that of the non-neuroinvasive patients(22.7% vs 40.7%,P=0.001),and the 5-year overall survival rate was significantly lower than that of the non-neuroinvasive patients(22.5% vs.44.9%,P<0.001).Cox multivariate analysis showed that neuroinvasion was an independent prognostic factor for esophageal squamous carcinoma(P= 0.001).There was no statistical significance(P>0.05)in the subgroup analysis of patients with neuroinvasion and stage Ⅲ non-divine aggression,no disease survival rate and overall survival rate.Conclusion:Perineural Invasion indicates the late stage of esophageal squamous cell carcinoma.Perineural Invasion is an independent prognostic factor for esophageal squamous cell carcinoma. |
PDF Full Text Request