Relevance Of Brain Metastasis On Cognitive And Quality Of Life In Patients With Lung Cancer

Objective:To investigate the differences of neurocognitive function with brain metastasis and non-brain metastasis of lung cancer patients matched with demographics,pathological types,staging,number of cycles of chemotherapy,KPS score and so on.Methods:A total of 41 newly diagnosed lung cancer patients with brain metastase were enrolled in this study as experimental group.According to certain conditions,41 patients with non-brain metastases from lung cancer were treated with 1:1 matching.The two groups were evaluated by the Montreal Assessment Scale(MOCA)and the Mini-Mental State Examination Scale(MMSE).The quality of life of the two groups of patients was assessed by the Alzheimer's Disease Cooperative Research Daily Capacity Scale(ADCS-ADL).An independent sample t-test was used to compare the differences in cognitive function and quality of life between patients with brain metastases and those non-brain metastases.Results:(1)Results of MOCA assessment:Of the 38 lung cancer patients with brain metastasis who completed the MOCA scale,34(90%)cases had cognitive impairment,in which 28(74%)cases of mild cognitive impairment and 6(16%)cases of dementia;Of the 41 lung cancer patients with non-brain metastasis,33(81%)cases had cognitive impairment,in which 31(76%)cases of mild cognitive impairment and 2(5%)cases of dementia;Results of MMSE assessment: :Of the 38 lung cancer patients with brain metastasis who completed the MMSE scale,24(68%)cases had cognitive impairment.And of 41non-brain metastatic lung cancer patients,18(44%)cases were present as cognitive dysfunction.Comparing brain metastases with non-brain metastases of lung cancer patients,the results suggest that the result in the cognitive function of lung cancer patients with brain metastasis had a significant decrease(P<0.05).At the same time,the visual acuityand ability to perform,attention in MOCA subitems analysis was significantly correlated with cognitive function decline,as well as attention and computational power in the MMSE subitems analysis(P<0.05).(2)The quality of life of 41 patients with lung cancer brain metastases and 41 patients with non-brain metastases were evaluated.The results suggest that brain metastasis results in a significant decrease in the quality of life of lung cancer patients(P<0.05).Conclusion:(1)Regardless of the presence or absence of brain metastases,there is a certain degree of cognitive impairment in lung cancer patients;for lung cancer patients,under the same conditions,brain metastases make the cognitive function of lung cancer patients further decline.(2)Under the same conditions,lung cancer patients with brain metastasis had significantly decrease in quality of life.