Clinicopathological Characteristics And Survival Analysisof Female Breast Cancer Cases With Different HER-2 Status

Objective: To investigate clinicopathological characteristics and prognosis of breast cancer with various human epidermal growth factor receptor 2(HER-2)status.Methods:Clinicopathological characteristics of 1912 newly diagnosed female breast cancer patients were included during August 2012 to August 2014.HER-2 status was divided into HER-2positive group and HER-2 negative group.Clinical features and prognosis of these breast cancer patients were analyzed.Results: Among 1912 cases,HER-2 positive and HER-2negative patients took up 30.9%,69.1% respectively.Distant metastasis rate,3-year overall survival(OS)status and 3-year progression-free survival(PFS)status of HER-2positive breast cancer was significantly different from HER-2 negative breast cancer(P<0.05).When confined to HER-2 positive patients,target-treated patients have longer three-year OS than untreated patients(97.7% vs 91.7%,P<0.05).Multivariate analysis revealed that HER-2 status,endocrine therapy,chemotherapy and targeted-therapy were independent prognostic factors of OS and PFS.Vessel tumor thrombus,tumor diameter,lymph node status were independent prognostic factors of OS.Race was the independent prognostic factor of PFS.Subgroup analyse showed age,endocrine therapy were independently predictable for HER-2 negative breast cancer.Conclusion: The main type of breast cancer in Xinjiang is invasive ductal carcinoma,the positive rate of HER-2expression is 30.9% and it has tended to occur among younger women.HER-2 status,endocrine therapy,chemotherapy and targeted-therapy may provide important information to predict the prognosis of breast cancer.Race is independent prognostic factor of PFS.