Quantitative Shear Wave Elastography Of Liver Stiffness:Comparison Of Hepatocarcinoma And Hepatitis B Cirrhosis

ObjectiveThe purpose of this study was to investigate the value liver stiffness in patients with hepatocarcinoma or hepatitis B cirrhosis using the shear wave elastography?SWE?and to carry out a comparative analysis of their liver stiffness.we explore the liver stiffness of hepatocarcinoma,in order to provide a helpful method that clinical monitoring the progress for hepatitis B liver cirrhosis and hepatocarcinoma,and preventing the hepatocarcinoma timely.MethodThis study was approved by the ethics committee of our hospital,written informed consent was obtained from all patiens before their enrollment in the period between June 2017and February 2018.ALL patients?hepatocarcinoma?hepatitis B cirrhosis and healthy volunteer?were examined with SWE and underwent serologic testing to measure liver stiffness.The maxima,minima,means,standard deviations of SWE measurements expresses in kilopascals(E_max,E_min,E_mean,E_SD),were obtained for liver stiffness which were around the lesion in hepatocarcinoma group?within 2cm?,and liver parenchyma of S5/6 for three groups in five times.Analyze the characteristics and differences between the three groups.All data were processed by SPSS 17 statistical software.The level of statistical inference was?=0.05,P<0.05,and the difference was statistically significant.Result1.In this study,there were significant differences in the serum indexes of ALT,AST,DBIL,AFP,CA125,ALB,GLB,PLT between the hepatocarcinoma group and the cirrhosis group.However,there were no significant difference in the serum indexes of TBIL,IBIL,CEA,TP,type III procollagen N end peptide,laminin,type IV collagen and hyaluronic acid between them?P>0.05?.The enlargement of the spleen and ascites were significant differences between them.The age and sex were no significant for the three groups.2.The E_mean values for liver stiffness which were around the lesion in hepatocarcinoma group?within 2cm;24.7±15.2kPa?were significantly higher than the liver parenchyma of S5/6?12.7±7.3kPa?.The E_mean values for the liver parenchyma of S5/6 in hepatocarcinoma group?12.7±7.3kPa?were lower than those of cirrhosis group?13.6±6.9kPa?.The E_mean values for liver stiffness were significant difference in the liver parenchyma of S5/6 for three groups.3.The E_max values for liver stiffness which were around the lesion in hepatocarcinoma group?within 2cm;36.0±26.3kPa?were significantly higher than the liver parenchyma of S5/6?17.2±9.9kPa?.The E_max values for the liver parenchyma of S5/6 in hepatocarcinoma group were no significant difference in those of cirrhosis group?16.8±8.3kPa kPa?.4.The E_max and E_mean values for the liver parenchyma of S5/6 in hepatoca rcinoma group who with cirrhosis(The E_max:22.6?30.0kPa,E_mean:17.1?6.6 kPa)were significantly higher than those of cirrhosis group.5.The Emax and Emean values for liver stiffness which were around the lesion in hepatocarcinoma group who with small hepatocarcinoma(within 2cm;the liver parenchyma of S5/6(The Emax:22..6.The E_max and E_mean values for liver stiffness which were around the lesion in hepatocarcinoma group who without small hepatocarcinoma(within 2cm;The E_max:37.5?26.9 kPa,E_mean:25.9?14.2kPa)were significantly higher than the liver parenchyma of S5/6(The E_max:17.9?7.5 kPa,E_mean:16.6?4.6 kPa).7.There was no significant difference in the E_max and E_mean liver stiffness values which were around the lesion in hepatocarcinoma group between the small hepatocarcinoma and without small hepatocarcinoma.There was no significant difference in the E_mean liver stiffness values which were the liver parenchyma of S5/6 in hepatocarcinoma group between them.But The E_max values for the liver parenchyma of S5/6 in hepatocarcinoma group who with small hepatocarcinoma were significant difference in those without small hepatocarcinoma.Conclusion1.There was no significant difference in the age and sex between the hepatocarcinoma group,the cirrhosis group and the healthy group,but the liver function and the cancer markers in the hepatocarcinoma group were more serious than those in the cirrhosis group.2.The E_max and E_mean values for liver stiffness which were around the lesion in hepatocarcinoma group were significantly higher than the liver parenchyma of S5/6.3.The E_mean values for the liver parenchyma of S5/6 in hepatocarcinoma group were lower than those of cirrhosis group.The E_max values for the liver parenchyma of S5/6 in hepatocarcinoma group were no significant difference in those of cirrhosis group.The E_max and E_mean values for the liver parenchyma of S5/6 in hepatocarcinoma group who with cirrhosis were significantly higher than those of cirrhosis group.4.The E_mean values for liver stiffness were significant difference in the liver parenchyma of S5/6 for three groups.5.There was no significant difference in the Emax and Emean liver stiffness values which were around the lesion in hepatocarcinoma group between the small hepatocarcinoma and without small hepatocarcinoma.Both in the Emean liver stiffness values which were the liver parenchyma of S5/6 in hepatocarcinoma group between them.But The Emax values for the liver parenchyma of S5/6 in hepatocarcinoma group who with small hepatocarcinoma were higher than those without small hepatocarcinoma.Therefore,it needs to be further discussed.