Study On Preparation Technology And Quality Standard Of Xiaoer Feiyan Cataplasm

Pediatric pneumonia is a common disease in childhood and seriously endangers children's health.It can cause a variety of complications,affecting children's growth and health.Xiaoer feiyan cataplasms is composed of rhubarb,skullcap,Morus alba,Glauber's salt four herbs consisting of compound preparation.This prescription is a clinical prescription that has been used for a long time.It has functions such as heat-clearing,detoxifying,and evading lung and relieving asthma.There is no mature topical dosage form in clinical practice.Due to the large amount of drug contained in the cataplasm,good drug release performance,low stimulation to the gastrointestinal tract,accurate dosage,avoidance of first-pass effect,low toxic and side effects,convenient use,and can be used to stop the drug and repeatedly adhere to the dosage form Characteristics,so this topic researched preparation of the Xiaoer feiyan cataplasms.This topic from the Xiaoer feiyan cataplasms This topic is studied from the aspects of extraction process,preparation process and quality standard of the Xiaoer feiyan cataplasms.According to the physicochemical properties and pharmacological effects of various pharmacological substances in the Xiaoer feiyan cataplasms,single factor investigation and orthogonal design were used to optimize the optimal extraction process.It was determined that the best extraction process of Radix Astragali was 70%ethanol,and the reflux time was 2 hours in 2 times.The best extraction process of rhubarb was 80%ethanol,and the reflux time was 2.5 h,and extraction was performed 3 times.The best extraction process of Morus alba was 60%ethanol,reflux time was 1.5h,reflux extraction was performed 3 times.The weighted comprehensive scores of initial viscosity,stickiness,and sensory scores(appearance,softness,spreadability,residual film,and skin follow-up)were used as indicators,and single-factor studies and star-point design experiments were used to optimize the effect surface.Formulation prescription.The amount of transdermal absorption enhancer was screened by Franz diffusion cell method.The final formulation was determined to be NP-700:PVP:aluminum glycerol:glycerol:carbomer:tartaric acid:azone(4.56:3.95:0.8:1 5:4:0.2:1.2).This topic has qualitatively and quantitatively studied the quality of the formulation.Thin-layer chromatography was used to qualitatively identify rhubarb and mulberry skin in pediatric pneumonia cataplasm.HPLC was used to determine the content of baicalin,and the quality standard was initially established.The results show that this method is feasible,scientific and reliable,and provides a reliable basis for quality control of preparations.Through this study,the extraction and preparation process of the Xiaoer feiyan cataplasms was optimized,and the quality standard of the Xiaoer feiyan cataplasms was initially established,which laid the foundation for the development of the Xiaoer feiyan cataplasms.