The Curative Effect Observation Of The Method Of Strengthens The Immune System Combined Leflunomide On Treatment Of The Rheumatoid Arthritis In Remission

ObjectiveThis research topic is to inherit and carry forward guangdong province famous eld doctor of traditional Chinese medicine of He Shidong professor's main academic thoughts of syndrome differentiation rheumatism arthritis.Based on the method of strengthens the immune system of professor he curative effect observation in the cure of rheumatoid arthritis research.In the wish of looking for traditional Chinese medicine to control the disease for a long time,valid and secure way.MethodMaking use of Simple randomization design,make 70 RA patients who were included in the standard were randomly be split into two groups,include treatment group and control group,40 patients were included in the treatment groups,control group has 30 cases.Treatment group use traditional chinese medicine(Astragalus membranaceus 12 g,Atractylodes15g,Lycium spp 10 g,Dried rehmannia root 15 g,Longspur epimedium 10 g,Herba taxilli 15 g,Pawpaw12g,Eleutherococcus senticosus 15 g,Scorpion 3g,Caulis spatholobi15 g,Rhizoma drynariae10 g,earthworm8g),daily 1 agent,decoction to 400 ml,morning and evening temperature for 1 second+LEF10mg/time,1time/d,the control group use LEF 10 mg,10 mg/time,1 / d monotherapy,In TCM syndrome integral,simplify the disease activity index(SDAI)and bilateral carpal tunnel of high frequency ultrasound change as the main observation indexes,To observe the treatment36 weeks,observed in 4 weeks,12 weeks and 24 weeks,36 weeks follow-up and condition assessment,Recorded SDAI,synovial membrane thickness,blood flow resistance and flow distribution,degree of bone erosion before and after treatment,to evaluate standard under the two plans to maintain the curative effect of treatment,recurrence rate calculation.Results(1)in treatment group,14 cases continue to ease,low disease activity in 189 cases,7 cases of middle and high mobility,the total effective rate was 82.5%.Control group continue to ease 9 cases,low disease activity in11 cases,10 cases of middle and high mobility,fall off in 2 cases,total effective rate was 66.67%.(2)Before and after treatment in patients with TCM syndrome integral statistically significant(P<0.05),The effect of the treatment group was more significant than in the control group.(3)Comparison of the two groups before and after the treatment of wrist joint variable value of high frequency ultrasound,the comparison between groups,double slide film thickness before and after treatment,blood flow distribution,RI values were no significant difference(P > 0.05);Comparison group,the treatment group and control group before and after treatment double slide film thickness,blood flow distribution,RI values have significant difference(P < 0.05).(4)In the two groups before and after the treatment with no adverse reactions,the routine of blood and urine,the function test of liver andrenal are no exception.Conclusion(1)The decoction of Strengthens the immune system combined with Leflunomide to maintain standard treatment of rheumatoid arthritis has good effect,can keeping a disease in a stable state.(2)The decoction of Strengthens the immune system can improve clinical curative effect obviously,the patient's clinical symptoms,TCM syndrome,the quality of life can be improved,Its curative effect has certain security,worthy of promotion,long-term use.(3)High frequency ultrasound for remission of RA patients,is a sensitive observation index for curative effect of RA,can intuitive observation RA joint synovitis.