Clinical Study Of Chai Qin Ning Shen Decoction In The Treatment Of Liver Qi Stagnation Insomnia

Objective: To observe the clinical efficacy and safety of Chai Qin Ning Shen Decoction in treating insomnia due to stagnation of liver qi.Methods: 66 patients with insomnia were randomly selected and divided into two groups randomly according to the proportion of 1:1: 33 cases of Chai Qin Ning Shen Decoction group(test group),and 33 cases of BaiCao Xiang Jieyu Anshen capsule group(control group).Drug delivery scheme: the test group was given Chai Qin Ning Shen Tang,warm water,100ml/ times,every time in the morning and evening,and the control group was given oral white herb Jieyu Anshen capsule,4 after dinner,4 before bedtime,and 4 weeks for a course of treatment.The efficacy of TCM syndromes,curative effect of single symptom,PSQI score,HAMA score and SDNN score were compared between the two groups before and after treatment.Result:1.The curative effect of TCM syndrome of insomnia: after treatment,the total effective rate of Chai Qin Ning Shen decoction was 87.1%,the total effective rate of BaiCao Xiang Jieyu Anshen capsule was 63.3%,and the difference between the two groups was statistically significant(P < 0.05),and the experimental group was better than the control group.2.The curative effect of single symptom of insomnia: after treatment,there was a significant difference between the control group and the control group(P < 0.05),but there was no significant difference between the experimental group and the control group(P >0.05).3.PSQI scale integral change: after treatment,the difference of sleep quality score,sleep time score and daytime dysfunction score in two groups of PSQI total and sleep factors were statistically significant(P=0.020 < 0.05,P=0.028 < 0.05,P=0.048 < 0.05,P=0.016 <0.05),indicating that the test group was reducing the total PSQI total.The effect of improving sleep quality,shortening sleep time and improving daytime dysfunction was better than that of the control group,while there was no significant difference between the other sleep factor scores in the control group(P > 0.05).4.HAMA scale integral change: after treatment,the total score of HAMA between the two groups was statistically significant(P < 0.05),and the experimental group was better than the control group.5.SDNN score changes: after treatment,there was a significant difference in the contrast between the two groups of SDNN scores(P < 0.05),and there was no significant differencebetween the groups(P > 0.05),and the effect of the test group was similar to the control group.6.Safety evaluation: no adverse reactions occurred in the two groups,and no safety examination was found.Conclusion: Chai Qin Ning Shen Tang Decoction is effective in the treatment of stagnation of liver qi stagnation type insomnia.It is obviously better than BaiCao Xiang Jieyu Anshen capsule in TCM syndrome curative effect,sleep quality and anxiety symptom improvement,and the curative effect of this prescription on insomnia accompanied by autonomic nervous dysfunction is equivalent to that of BaiCao Xiang Jieyu Anshen capsule.Chai Qin Ning Shen decoction is safe and effective in treating insomnia due to liver qi stagnation,and has no obvious toxic and side effects.