| Objectives To observe the curative effect,the stability of the curative effect,the effect of clinical symptom improvement and the effect on the liver function of the decoction of Tongfu and atorvastatin in the treatment of hyperlipidemia and stagnation of phlegm and stasis.Methods 1 from June 2016 to December 2017,80 cases of hyperlipidemia were collected from TCM department of Tongzhou District,Beijing.2 randomly divided into observation group and control group,40 cases in each group.3 the observation group took Tongfu Xiezhuo prescription compound granule of Tongfu Xiezhuo prescription orally 1 dose per day,and the control group took Atto vastatin calcium capsule 10 mg QD orally once a day,twice in the morning and evening,while the control group took orally Atto vastatin calcium capsule once a day.The treatment period was 6 weeks in both groups.4 the blood lipid,liver function index and TCM syndrome score data were collected before and after treatment in two groups of patients,and the blood lipid indexes were collected after 2 weeks of drug withdrawal.The data were statistically analyzed.Results 1 Clinical curative effect of western medicine: after 6 weeks of treatment,the observation group had 8 cases of clinical control,8 cases of marked effect,18 cases of effective,6 cases of ineffective,total effective rate of 85%.In the control group,9 cases were clinically controlled,12 cases were effective,16 cases were effective,3 cases were ineffective,and the total effective rate was 92.5%.Statistical analysis showed that there was no significant difference between the two groups in the clinical efficacy of western medicine(P > 0.05).2 Clinical efficacy of TCM: after 6 weeks of treatment,the observation group had clinical control in 3 cases,remarkable effect in 16 cases,effective in 20 cases,ineffective in 1 case,total effective rate in 97.5 cases,in the control group,1 case was controlled clinically,6 cases were effective,24 cases were effective,9 cases were ineffective,and the total effective rate was 77.5%.Statistical analysis showed that there were significant differences in clinical efficacy between the two groups(P < 0.05),and the observation group was superior to the control group.3 Cholesterol(TC): the serum total cholesterol levels were 7.88 ±1.21,5.79 ±0.85 before and after treatment in the observation group and 7.97 ±0.98,5.26 ±1.24 in the control group before and after treatment.The decrease of TC(P in both groups was lower than that in the observation group(P < 0.05),and the decrease in the control group was larger than that in the observation group(P < 0.05).After 2 weeks of withdrawal,there was no significant rebound in TC in both groups(P > 0.05).4 Triglyceride(TG):The observation group was 3.25 ±0.72,1.66 ±0.56 before and after treatment,and the control group was 3.05 ±0.64,1.90 ±0.58 before and after treatment.Both groups were able to reduce TG(P < 0.05)to some extent,and there was no significant difference between the two groups after treatment(P > 0.05).After 2 weeks of withdrawal,no significant rebound in TG was found in both groups(P > 0.05).5 Low density lipoprotein cholesterol(LDLC):The observation group was 4.21 ±0.32,3.41 ±0.36 before and after treatment,and the control group was 4.19 ±0.26,3.49 ±0.29 before and after treatment.Both groups could reduce LDLC(P < 0.05,and there was no significant difference between the two groups after treatment(P > 0.05).Two weeks after withdrawal,no significant rebound in LDLC was found in both groups(P > 0.05).6 How density lipoprotein cholesterol(HDLC):Before and after treatment,1.20 ±0.10,1.21 ±0.11 in the observation group and 1.18 ±0.11,1.19 ±0.10 in the control group.There was a slight increase in HDLC after treatment in both groups,but there was no significant difference between the two groups(P > 0.05).After 2 weeks of withdrawal,there was no significant rebound in HDLC index(P > 0.05).7 Safety evaluation: ALT before and after treatment was 24.07 ±4.31,23.92 ±4.49 in the observation group,23.27±4.23,29.57±5.83 in the control group,24.67 ±5.63,24.55 ±5.50 in the observation group,24.65 ±5.18,29.40 ±7.00 in the control group.before and after treatment.After treatment,the ALT Tvalues of AST in both groups were within normal range.There was no significant change in AST before and after treatment in the observation group(P > 0.05)and no significant change in ALT before and after treatment(P > 0.05).After treatment,ALT,AST in the control group was higher than that before treatment.Conclusions 1 both Tongfu Xiezhuo recipe and Atto vastatin could decrease the blood TC,TGP,LDLC index.2 Atto vastatin could decrease TCsignificantly.3 There was no significant difference in HDL effect between Tongfu and Atorvastatin.4 neither Tongfu Xiezhuo prescription group nor Atto vastatin group showed blood lipid rebound after 2 weeks of withdrawal.5 both Tongfu Xiezhuo recipe and Atto vastatin could improve the clinical symptoms of the patients,and Tongfu Xiezhuo recipe was superior to Atto vastatin.6 before and after treatment,Tongfu Xiezhuo recipe had no effect on alt AST,Atto vastatin could increase alt AST. |
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