Association Of MBL2 Genetic Polymorphisms With The Risk Of Lung Cancer

Objectives Mannan-binding lectin(MBL),as one of pattern recognition receptors in complement system,plays an important role in the development of lung cancer.The polymorphism of MBL may effect on the risk of lung cancer.The purpose of this study is to investigate the association of genetic variant of MBL with the susceptibility for lung cancer.Methods This case-control study included in 706 non-small cell lung cancer(NSCLC)patients and 706 healthy controls.The genotypes of MBL2 rs11003125 C>G and rs1800450 G>A variants were determined by polymerase chain reaction-based restriction fragment length polymorphism(PCR-RFLP).The Odds ratios(OR)and 95% Confidence I nterval(CI)were calculated by logistic regression to evaluate the associations of MBL2 genetic variants with the risk of lung cancer.Results Compared with MBL2 rs11003125 CC genotype carriers,CG genotype carriers had a significant decreased risk of developing NSCLC(P = 0.010)with OR(95%CI)of 0.73(0.57-0.93).When stratified by age for rs11003125,CG genotype carriers had a decreased risk only among youngers(age ?60)(P = 0.015)with OR(95%CI)of 0.67(0.48-0.92),but not among olders(age>60)with OR(95%CI)of 0.83(0.57-1.19).When stratified by smoking status,rs11003125 CG genotype carriers had a decreased risk among smokers(P = 0.023)with OR(95%CI)of 0.61(0.40-0.92),but not among non-smokers(OR = 0.80,95%CI = 0.59-1.09).There was no significant difference in MBL2 rs1800450 G>A genotype distribution between patients and controls(P > 0.05).Conclusions MBL2 genetic variant rs11003125 CG may reduce the risk of NSCLC in Chinese population.