Treatment And Survival Analysis Of Pyriform Sinus Carcinoma

Objective: To summarize and analyze the efficacy of surgery for the patients with pyriform sinus carcinoma and the prognostic factors ralated to the cancer.Methods: A retrospective analysis was made of 163 patients with pyriform sinus carcinoma admitted and operated in the First Affiliated Hospital of China Medical University from January 2010 to December 2014.According to TNM staged,there were 1patient staged in T1,30 in T2,100 in T3,32 in T4,and 42 in N0,29 in N1,81 in N2,11 in N3.These patients were divided into two groups according to the different methods of treatment and operation:34 cases in simple surgery group and 129 cases in surgery combined with radiotherapy group,46 cases in laryngeal function retention group and117 cases in unreserved laryngeal function group,The survival rate and survival curve were calculated by Kaplan-Meier method,and single factor analysis of prognosis was carried out.Log-rank was used to test each group.The Cox regression model was used to analyze the factors that affect the prognosis of patients with multi factor survival analysis.When P<0.05,it was considered statistically significant.Rusults: The survival rate was calculated with Kaplan-Meier method.The overala 3 and5 year survival rates were 50.8% and 38.1%,respectively.The 3 year survival rates in the non lymph node metastasis group and the lymph node metastasis group were 77.6% and40.9%,and the 5 year survival rates were 59% and 30%,respectively.The 3 year survival rate of laryngeal function group and unreserved laryngeal function group were 63.1% and49.2%,respectively.The 5 year survival rate was 53.3% and 29.8%,respectively.The 3year survival rate of simple surgery group and surgery combined radiotherapy group was79.4% and 42.2% respectively,and the 5 year survival rate was 61.8% and 30.7%,respectively.The above three groups were all P<0.05.The single factor analysis showed that there was a significant difference between each group.The multiple factor analysis of the Cox regression model found that the metastasis of cervical lymph nodes was an independent factor affecting the prognosis of the patients.Conclusions: Early diagnosis,early treatment and effective cervical lymph node dissection can improve the survival rate of patients with pyriform sinus carcinoma.Early diagnosis and timely and effective cervical lymph node dissection can improve the survival rate of patients with pyriform fossa carcinoma.