The Clinical Observation Of Diabetic Gastroparesis Was Treated With Relieving The Depressed Liver And Regulating Stomach

Objectives: To observe the clinical effect of soothing the liver and the stomach,and regulating qi in treating diabetic gastroparesis,to provide more therapeutic ideas and effective methods of the treatment,and to explore its TCM mechanism.Method: Among the inpatients and outpatients in the Endocrinology Department of Tianshui traditional Chinese Medicine Hospital,60 patients who met the diagnostic criteria of DGP were randomly divided into observation group(n=30)and control group(n=30).Before treatment,specific diet and exercise plans were made for both groups.The original hypoglycemic regimen was not changed,and the treatment of gastroparesis was not given for either groups.The observation group was treated with traditional Chinese herbal decoction which soothes the liver and stomach and regulates the energy flow.The control group took 10 mg of domperidone tablets with warm water,3 times a day,30 minutes before meals.The courses of the treatments were both 30 days.The curative effects of the two groups were contrasted by comparing the symptoms scores before and after treatment,such as fasting and postprandial blood glucose,glycosylated hemoglobin and safety indexes.Results: 1.Comparison between FPG and 2hPG: the FPG and 2hPG of the two groups were significantly lower after the treatment;the difference was statistically significant(P <0.05).Compared with the control group,the observation group performed better at decreasing FPG and 2hPG(P < 0.05),and the difference between the two groups was statistically significant(P < 0.05).The observation group was superior to the control group in this aspect.2.Comparison of HbAlc: after the treatment,HbAlc was improved in both groups,but there was no significant statistical difference between the two groups(P > 0.05).3.Comparison of clinical symptom efficacy: Among the observation group:11 cases showed improvement,16 cases were proven to be effective,and 3 cases showed no significant improvement.Among the control group: 2 cases showed improvement,18 caseswere proven to be effective,and 10 cases showed no significant improvement.There was significant difference in the total curative effect between the two groups(P < 0.05),and the effect of symptom improvement in the observation group was better than that in the control group.After treatment,the total symptom score of the two groups and the main epigastric symptoms(epigastric distention,abdominal pain,dry mouth,bitter mouth,and belching)were compared,and there were significant statistical differences(P < 0.05).However,for secondary symptoms(fatigue,constipation,diet reduction,etc.),there were no significant statistical differences(P > 0.05)between the two groups.4.Comprehensive curative effect comparison: the total effective rate of the observation group was 86.6% and the total effective rate of the control group was 60.0%.The overall curative effect of the observation group was better than that of the control group.5.There was no drug allergy or discomfort during the treatment.Conclusion: The methods of soothing the liver and stomach and regulating qi are superior to domperidone in improving the clinical symptoms of patients with DGP,and have a positive effect on the control of fasting and 2 hours postprandial blood glucose levels.The results showed that the therapeutic effect of this herbal decoction method on diabetic gastroparesis was obvious,and its mechanism was mainly related to relieving the state of depression and anxiety,and regulating and improving gastrointestinal motility through regulating qi.