The Method Of Disperse The Depressed Liver-energy And Invigorate The Spleen To Treat The Diabetic Gastroparesis On Clinical Observation

The diabetic gastroparesis (DGP) is one of the familiar complication of diabetes. According to domestic and international relevant data manifestation, 50% diabetic with 76% erupt DGP. The DGP is obvious influence medicine of absorb, thus influence diabetes of condition of control and sufferer of existence quality. The Chinese medicine has already display in the DGP pleased of tendency. This topic of research meaning, the aim is pass a sorting thou now a great deal of cultural heritage and clinical report way, combine my tutor of clinical experience, put forward stagnation of liver-QI with deficiency of the spleen is the DGP of importance the pathogenesy of the disease, and observation tutor empirical formula "the disperse the depressed liver-energy and invigorate the spleen herbal medicine "(temporary assign name to) at clinical top treatment on the clinical curative effect of the DGP, will provide importance of way of thinking and method for the Chinese medicine treatment of DGP for aftertime, have importance of theories meaning with clinical instruction value.Objective: By the way of Clinical Observation ,the observation clinical curative effect and safety of the mothod of disperse the depressed liver-energy and invigorate the spleen to treat the Diabetic gastroparesis, and first step study its mechanism of action, and opposite western medicine the advantage place of Domperidone, for clinical provide basis.Methods: Will bring into the DGP sufferer's 62, according to random of the principle is divided into treatment group and control group, 31 for each. At general decline a sugar treatment foundation up, the treatment group give the method of disperse the depressed liver-energy and invigorate the spleen in medicine treatment(temporary assign name to disperse the depressed liver-energy and invigorate the spleen herbal medicine), does the control group give the Domperidone 1.0mg, everyday three times, meal the first 30 minute take orally. After one course of treatment (4 weeks), pass a basis to the clinical symptom, blood sugar, motilin level, stomach row empty rate etc. observation index sign, according to symptom integral calculus, stomach row empty rate and motilin be a curative effect evaluation index sign, carry on statistics analysis, compare with two groups curative effect. Results: The (1) clinical curative effect:Two groups of clinical curative effect are all better than the pretherapy (P<0.01), treatment group is better than control group (P<0. 01). The treatment group cure 5(16.13%), special valid 17(54. 84%), valid 8(25. 8%), invalid 1(3.23%), total efficient 96. 77%, the control group cure 0, Special valid 12(38. 71%), valid 14(45.16%), invalid 5(16.13%), total efficient 83.87%; (2) Symptom integral calculus:Two groups of clinical symptom all had conspicuous amendment, treatment group symptom improvement is obvious better than control group (P<0. 01). With visit the symptom integral calculus of a month and two month difference all have already shown conspicuous (P<0. 01) ;(3) Stomach the row be empty:Two groups of stomach row empty rate(4h) To compare with pretherapy all have obvious increment(P<0. 01), treatment group 83. 71±10.80, control group 63. 23±12. 22, treatment group is obvious better than control group (P<0. 01); (4) motilin(MOT): Two groups of blood plasma motilin is obvious to descend than the pretherapy (P<0. 01) ;Treatment group had descend obviously than control group, statistics have already significance difference. (P<0. 05); (5)The blood sugar, glycosylated hemoglobin: Two groups of empty stomach and after mealtwo hour's postprandial blood sugar, glycosylated hemoglobin compare treatment front all have already descend(P<0. 05). Two groups of comparison, the after mealtwo hour's postprandial blood sugar and glycosylated hemoglobin all have already statistical significance (P<0.05), treatment group is better than control group.Conclusions: The disperse the depressed liver-energy and invigorate the spleen herbal medicine can be obvious improvement the DGP sufferer's clinical symptom, increment stomach row empty rate, improvement stomach and intestines peristalsis function, obvious shorten stomach row empty time, be advantageous to blood sugar (the after mealtwo hour's blood sugar and glycosylated hemoglobin) of control, the method of disperse the depressed liver-energy and invigorate the spleen to the diabetic gastroparesis have a good curative effect. Should function possible relevant with it could control blood sugar steady, strengthen stomach motive, promote stomach row empty, alleviate spirit stimulate, worry anxiously, suppress etc. bad emotion stimulus, improvement independence nerve function, regulate stomach and intestines hormone, regulate stomach and intestines sport.