| Objective:This topic through the observation of the improvement situation of the clinical symptoms and the quality of life in patients with functional dyspepsia, aiming to assess the efficacy of Shugan Jianpi Hewei decoction objectively and popularize its clinical application further, by using self-made Shugan Jianpi Hewei decoction to treat patients with functional dyspepsia of liver-stomach disharmony.Methods:On the basis of the randomized,controlled clinical trial principle,60 cases of patients with liver-stomach disharmony type functional dyspepsia were selected in the light of the inclusion criteria of this study, which randomly divided into treatment group and control group, each of 30 cases in accordance with its order of clinic visits. Treatment group was treated with self-made Shugan Jianpi Hewei decoction, while the control group received only oral Mosapride Citrate Sheet,4 weeks for a course of treatment. The curative effect and adverse reaction of the two groups were observed before and after treatment, and the control was analyzed in parallel.Results:1 The overall clinical efficacy:The total effective rate of the treatment group and the control group were 93.33% and 70% respectively, the difference was statistically significant (P＜0.05), the treatment group was better than the control group.2 The total integral comparison of TCM symptoms before and after treatment:There was no statistical difference in the total score of the two groups before treatment(P>0.05). After treatment, the total score of the two groups were significantly decreased compared with before treatment(P<0.01), treatment group symptom total score was significantly lower than that of the control group(P＜0.01).3 The single effect of main symptoms:The effective rate of the treatment group was 85.71%, 87.75%,92.85%, respectively, which was obviously higher than that in the control group, 52.60%,50%,44.44%, respectively, in the postprandial fullness, early satiety, upper abdominal pain, compared with statistically significant difference(P<0.05). The treatment group was superior to the control group in the improvement of the main symptoms.4 The comparison of individual score before and after treatment:There was no statistical difference in the individual score of the two groups before treatment(P>0.05). After treatment,the score of postprandial fullness, early satiety, upper abdominal pain,heartburn, acid reflux, two threatened fullness, chest deep sigh and loose stools of treatment group was significantly lower than the control group, with significant difference(P<0.01,P＜0.05); While the score of diet reduction, belching nausea compared with no significant difference(P>0.05),the curative effect is equivalent.5 The comparison of HAMA/HAMD score:There was no statistical difference in the HAMA/ HAMD score of the two groups before treatment(P>0.05). After treatment, the two groups of HAMA/HAMD score was obviously decreased compared with before treatment(P<0.01), and treatment group of HAMA/HAMD score compared with the control group also decreased significantly(P<0.05).Conclusion:The method of liver-soothing and spleen-regulating and stomach-harmonizing achieved remarkable efficacy in promoting clinical symptoms and quality of life, etc, in patients with functional dyspepsia. And no significant adverse reactions were found. It is worthy of clinical popularization and application. |
PDF Full Text Request