Incidence Of Venous Thrombosis In Lower Extremity And Related Risk Factors In Patients With Lung Cancer

Background and objective Lungs cancer is the first leading cause of morbidity and mortality among the melignant tumors.Lower extremity venous thrombosis(LEVT)includes deep venous thrombosis of lower extremity(LEDVT),superfical venous thrombosis of lower extremity(LESVT)and calf muscle venous thrombosis(CMVT),which is the main complication of lungs cancer.In this study,the clinical data of 203 patients with lung cancer in our center were retrospectively analyzed to calculate the incidence of LEVT in patients with lung cancer and to identify the relative risk factors of the occurrence of LEVT in patients with lung cancer.Methods From July 2017 to December 2017,we collected 247 patients data with lungs tumor in the General Hospital of Tianjin Medical University,including 203 cases of lungs cancer,83 cases of surgical treatment of the 203 cases;44 cases of benign pulmonary diseases,25 cases of surgical treatment of the 44 cases.The patients in both groups were immediately examined by color Doppler ultrasound of lower extremity vein upon admission,and the patients who were treated by operation were examined with color Doppler ultrasound again after operation.The LEVT of the patients was analyzed statistically.The changes of coagulation function and platelet in two groups were monitored at the same time to investigate the value of blood coagulation and platelet in patients with LEVT.SPSS software is used to calculate the data.P < 0.05 has statistical significance.Result All patients with pulmonary mass was monitored at admission.There were 9 cases of LEVT,and the incidence rate was 3.64%.LEVT was found in 8 patients with lung cancer,and the incidence rate was 3.96%;LEVT was found in 1 patient with benign lung disease,and the incidence was 2.72%.There was no statistical difference between the two groups.Plasma D-Dimer in 9 patients with LEVT was significantly higher than that in patients without LEVT(P < 0.05),but there was no significant difference in FIB and platelet.Patients with lung cancer were more likely to develop LEVT at admission with distant metastasis or smoking history.The D-Dimer level in 8 patients with lung cancer thrombosis was significantly higher than that in nonthrombotic lung cancer patients(P< 0.05),but there was no significant difference between FIB and platelets.All postoperative patients were monitored.There were 30 cases of LEVT,and the incidence rate of LEVT was 23.6%.There were 25 patients after lung cancer operation with LEVT,and the incidence rate of LEVT was 30.1%.There were 5 patients of postoperative benign pulmonary disease with LEVT,and the incidence rate was 20%.There was no statistical difference between the two groups.D-Dimer in 30 patients with thrombosis was significantly higher than that in non-thrombus patients on the 1st,the 3rd,the 5th day after operation(P < 0.05),and there was no significant difference between FIB and platelets.LEVT was more likely to occur in patients of postoperative lung cancer stage Ⅲ,Ⅳ or over 60 years of age(P < 0.05).D-Dimer in patients of lung cancer with LEVT was significantly higher than that in patients with lung cancer without LEVT on day 1,day3 and day 5 after operation(P < 0.05).FIB and platelets were not significantly different.Conclusion1.The overall incidence of LEVT with pulmonary mass was 3.64%,and the incidence of LEVT in patients with lung cancer was 3.96%,and the incidence of LEVT in patients with benign lung disease was 2.72%.There was no significant difference between the two groups.2.The D-Dimer of all thrombosis patients was significantly higher than that of non-thrombosis patients at admission(P < 0.05).3.Patients of lung cancer with distant metastasis or smoking history were more likely to develop LEVT upon admission,D-Dimer in patients of lung cancer with LEVT was significantly higher than that in patients of lung cancer with non-LEVT(P < 0.05).4.The total incidence of LEVT with lung tumor after operation was 23.6%,and the incidence of LEVT with postoperative lung cancer was 30.1%,and the incidence of LEVT with postoperative lung benign diseases was 20%,there was no statistical difference between two groups.5.D-Dimer in all patients with thrombus was significantly higher than that in patients with non-thrombus on the 1th,3rd and 5th day after operation(P < 0.05).6.Patients of lung cancer with stage Ⅲ,Ⅳ or age > 60 were more likely to develop LEVT after operation,and D-Dimer in postoperative lung cancer patients with LEVT was significantly higher than that in patients of postoperative lung cancer not with LEVT(P < 0.05).