Correlation Of PET-CTSUVmax And CT Enhancement Value With Lung Tumor Markers And Clinical Factors In Small Cell Lung Cancer

Objective To explore the change of gastrin-releasing peptide,neuron-specific enolase,PET-CT,SUVmax of primary tumor and CT enhancement of primary lung in patients with small cell lung cancer and non-small cell lung cancer,whicch was evaluated in relation to clinical factors in lung cancer and analyzed for its value in the diagnosis of small cell lung cancer.Methods We collected firstly diagnosed patients of small cell lung cancer and non-small cell lung cancer in our department of respiratory medicine and oncology from January 2015 to January 2018 in our hospital.We asked related medical history,ruled out severe renal insufficiency?cerebral hemorrhage?thyroid tumors?prostate tumors and other diseases.Finally,50 subjects were included in the study,including 42 males and 8females,24 patients with small cell lung cancer,26 patients with non-small cell lung cancer,26 patients with PET-CT(systemic),and 24 patients with pulmonary enhanced CT.Fifty patients need to be tested for lung tumor markers.According to the pathological type of lung cancer,the subjects were divided into two groups: 24 cases of small cell lung cancer(12 cases with PET-CT(systemic)and 12 cases with enhanced pulmonary CT),and 26 cases with non-small cell lung cancer(PET-CT(systemic)in 14 cases,lung enhancement CT in 12 cases).Patients were asked about their age,gender and smoking history.Serum gastrin-releasing peptide precursors,neuron-specific enolase concentrations,PET-CT lung tumor primary tumor SUVmax values,and lung tumor primary lesions were recorded.CT enhancement values were used to evaluate the clinical factors such as the size,pathological type,and metastasis of the primary tumor in the patient,and to observe the correlation between each index and its value in the diagnosis of small cell lung cancer.Results There was no significant difference in age,gender,number of smokers,tumor stage,tumor metastasis,and SUVmax of tumor primary tumor between the two groups(P>0.05).The CT tumor enhancement value was significantly different between the two groups(P<0.05).The primary tumor CT enhancement value of the SCLC group was higher than that of the NSCLC group.The tumor size was significantly different between the two groups(P<0.05).The primary tumor in the SCLC group was larger than that in the NSCLC group;the Pro-GRP and NSE were also have a significant difference between the two groups(P<0.05).The Pro-GRP and NSE significantly increased in the SCLC group.Correlation analysis showed that there was a significant positive correlation between SUVmax and the size of the primary tumor in the lung(r=0.409,P=0.038),and there was a significant correlation between the CT enhancement value and the pathological type(r=-0.434,P=0.034).In the SCLC group,the CT enhancement value of the primary tumor was higher than that of the NSCLC group;Pro-GRP were significantly associated with NSE(r=0.455,P=0.001)and pathological types(r=-0.789,P=0.000).NSE and Pro-GRP(r=0.455,P=0.001),pathological type(r=-0.491,P=0.000),primary tumor size(r=0.450,P=0.001),tumor metastasis(r=0.395,P=0.005)were significantly correlated(P<0.05).The area under the curve of the Pro-GRP was significantly greater than the area under the curve of the NSE?the area under the curve of the CT enhancement value,and the area under the curve of the SUVmax(AUC=0.571<0.7).Conclusions SUVmax and NSE can be used as effective predictors for the evaluation of primary tumor size;CT enhancement can be used as an effective index to evaluate the pathological type of lung cancer;Pro-GRP is more effective than other three indicators in the diagnosis of small cell lung cancer.high efficiency.