Diagnostic Value Of Pro-GRP?NSE And MSCT Signs In Small Cell Lung Cancer

Objective: To explore the diagnostic efficacy of Pro-GRP?NSE and MSCT in small cell lung cancer;to explore the differential diagnostic value of MSCT signs in different pathological types of lung cancer;and to explore the relationship between MSCT signs and Pro-GRP?NSE of different lung cancer types.Methods: Retrospective analysis of 318 lung cancer patients(including 78 small cell lung cancer and 240 non-small cell lung cancer)who underwent multi-layer chest CT scan,laboratory examination and clear pathological results from october 2016 to october 2019 in shaanxi province people's hospital.Pro-GRP and NSE lung radioimmunoassay were performed to record yin-yang properties and specific values.Thin-layer image data were obtained by canon 320 row and siemens 64 row CT scan,and axial and coronal position were obtained by post-processing software.The tumor margin,calcification,cavity,shape,liquefaction necrosis,bronchus were observed and recorded on the original image.lumen,bronchial wall,grinded glass changes,vascular cluster,growth pattern,hilar mediastinal lymph nodes,obstructive pneumonia,obstructive atelectasis,pericardial effusion,pleural effusion and bone destruction,and other signs were measured to measure tumor size,density,enhancement amplitude and other values.using epidemiological diagnostic experimental evaluation,two independent sample t test and four-grid form factor ?2 analysis,when P<0.05 difference was statistically significant.Results:1.There was no significant difference in age,sex,significant difference in age,sex,stage and prevalence of smoking and tuberculosis between SCLC and NSCLC groups(P<0.05).2.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and Yoden index in the diagnosis of SCLC were 80.76%,84.58%,5.24,0.23 and 0.65,respectively.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and Yoden index of NSE in diagnosing SCLC were 66.67%,73.33%,2.50,0.45 and 0.4,respectively.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and Yoden index of SCLC were 62.82%,70.83%,2.15,0.52 and 0.34,respectively.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and yoden index of pro-GRP +NSE in the diagnosis of SCLC were 85.90%,87.50%,6.87,0.15 and 0.73,respectively.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and Yoden index of Pro-GRP +NSE+MSCT in diagnosing SCLC were 89.74%,90.83%,9.77,0.11 and 0.81,respectively.3.The MSCT signs of tumor margin,shape,liquefaction necrosis,bronchial lumen,bronchial wall,growth pattern,hilar mediastinal lymph node,obstructive pneumonia,obstructive pulmonary atelectasis,pericardial effusion,bone destruction and so on SCLC group were statistically significant(P<0.05).the MSCT signs of tumor size,calcification,cavity,altered grinding glass,vascular cluster,pleural effusion and so on in SCLC group were not statistically significant(P>0.05).Tumor plain scan density of SCLC group was28.16±3.64 Hu,enhancement degree 26.98±13.67 Hu,NSCLC group,the tumor plain scan density was 29.07±4.52 Hu,the enhancement amplitude was 30.66 and 15.01.the difference was not statistically significant(P>0.05).4.The Pro-GRP expression of hilar mediastinal lymph mediastinal lymph node enlargement,fusion and pericardial effusion was statistically significant in 78 cases(P<0.05).The NSE expression level of hilar mediastinal lymph node fusion,obstructive atelectasis and bone destruction was statistically significant(P<0.05);between bronchial wall thickening,hilar mediastinal lymph nodes and signs of bone destruction NSE expression levels were compared and statistically significant(P<0.05).Conclusion:1?Pro-GRP?NSE combination MSCT can improve the diagnostic efficacy of SCLC;2?MSCT signs are helpful for the diagnosis of lung cancer and the pathological type of lung cancer;3?Pro-GRP level was associated with hilar mediastinal lymph node enlargement,fusion,pericardial effusion,hilar mediastinal lymph node fusion,obstructive,obstructive atelectasis,bone destruction were associated with NSE level;NSCLC fluid necrosis,hilar mediastinal lymph node fusion were associated with Pro-GRP level,bronchial wall thickening,hilar mediastinal lymph node fusion,bone destruction were associated with NSE level.